1,132 downloads
9,884 views

Importance Case reports describe persistent erectile dysfunction (PED) associated with exposure to 5α-reductase inhibitors (5α-RIs). Clinical trial reports and the manufacturers’ full prescribing information (FPI) for finasteride and dutasteride state that risk...

["Dermatology","Epidemiology","Internal Medicine","Pharmacology","Urology"]
doi:10.7717/peerj.3020
57 downloads
534 views

It has previously been shown that domestic dogs and their household owners share bacterial populations, and that sharing of bacteria between humans is facilitated through the presence of dogs in the household. However, less is known regarding the bacterial communities...

["Microbiology","Veterinary Medicine","Dermatology"]
doi:10.7717/peerj.3075
92 downloads
606 views

Localized genomic variability is crucial for the ongoing conflicts between infectious microbes and their hosts. An understanding of evolutionary and adaptive patterns associated with genomic variability will help guide development of vaccines and antimicrobial...

["Microbiology","Dermatology"]
doi:10.7717/peerj.2959
75 downloads
295 views

Background Multiple myeloma is a cancer which has a high occurrence rate and causes great injury to people worldwide. In recent years, many studies reported the effects of miRNA on the appearance of multiple myeloma. However, due to the differences of samples and...

["Genomics","Dermatology","Oncology"]
doi:10.7717/peerj.2831
73 downloads
304 views

The incidence of cutaneous melanoma (CM) has rapidly increased over the past four decades. CM is often overlooked in East Asian populations due to its low incidence, despite East Asia making up 22% of the world’s population. Since the 1990s, Caucasian populations...

["Dermatology","Epidemiology","Oncology","Public Health"]
doi:10.7717/peerj.2809
144 downloads
533 views

Objective The skin is an important immunological barrier of the body as well as an optimal route for vaccine administration. Gua Sha, which involves press-stroke treatment of the skin, is an effective folk therapy, widely accepted in East Asia, for various symptoms;...

["Dermatology","Immunology"]
doi:10.7717/peerj.2451
140 downloads
259 views

In aggressive solid tumors like melanoma, a strategy for therapy personalization can be achieved by combining high-throughput data on the patient’s specific tumor mutation and expression profiles. A remarkable case is dendritic cell-based immunotherapy, where tumor...

["Bioinformatics","Dermatology","Immunology"]
doi:10.7287/peerj.preprints.2385v1
125 downloads
382 views

Identification of appropriate reference genes (RGs) is critical to accurate data interpretation in quantitative real-time PCR (qPCR) experiments. In this study, we have utilised next generation RNA-sequencing (RNA-seq) to analyse the transcriptome of a panel of...

["Genomics","Molecular Biology","Dermatology","Oncology","Medical Genetics"]
doi:10.7287/peerj.preprints.2331v1
134 downloads
332 views

Background Global reports show that the antimicrobial-resistance of Propionibacterium acnes isolated from patients with acne vulgaris is becoming a large problem, making it necessary to find new therapeutic drugs. Methods In this study, 23 clinical isolates of...

["Microbiology","Dermatology","Infectious Diseases"]
doi:10.7287/peerj.preprints.2107v1
189 downloads
656 views

Skin diseases constitute an essential health and aesthetic problem in the elderly. The aim of the study was to evaluate the knowledge of the elderly residents of public nursing homes and participants of the University of the Third Age in Bialystok, Poland surrounding...

["Dermatology","Geriatrics","Public Health"]
doi:10.7717/peerj.2028
336 downloads
977 views

Background. Emerging research revealed the essential role of mitochondria in regulating stem/progenitor cell differentiation of neural progenitor cells, mesenchymal stem cells and other stem cells through reactive oxygen species (ROS), Notch or other signaling...

["Cell Biology","Developmental Biology","Dermatology","Pharmacology"]
doi:10.7717/peerj.1821
3 citations
354 downloads
1,056 views

Background. Resveratrol is a natural polyphenol that exhibits anti-inflammatory effects. The aim of this study was to investigate the effects of resveratrol treatment on epithelium-derived cytokines and epithelial apoptosis in a murine model of atopic dermatitis-like...

["Allergy and Clinical Immunology","Dermatology","Immunology"]
doi:10.7717/peerj.1889
305 downloads
695 views

Background. Leprosy reactions are acute inflammatory episodes that occur mainly in the multibacillary forms of the disease. The reactions are classified as type 1 (reverse reaction) or type 2 (erythema nodosum leprosum). Leprosy-associated oxidative stress has...

["Dermatology","Infectious Diseases","Metabolic Sciences"]
doi:10.7717/peerj.1799
179 downloads
192 views

Background. Emerging researches revealed the essential role of mitochondria in regulating stem/progenitor cell differentiation of neural progenitor cells, mesenchymal stem cells and other stem cells through reactive oxygen species (ROS), Notch or other signaling...

["Cell Biology","Developmental Biology","Dermatology","Pharmacology"]
doi:10.7287/peerj.preprints.1769v1
4 citations
1,107 downloads
10,176 views

An ever expanding body of research investigates the human microbiome in general and the skin microbiome in particular. Microbiomes vary greatly from individual to individual. Understanding the factors that account for this variation, however, has proven challenging,...

["Ecology","Evolutionary Studies","Genomics","Microbiology","Dermatology"]
doi:10.7717/peerj.1605

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