5 downloads
70 views

In aggressive solid tumors like melanoma, a strategy for therapy personalization can be achieved by combining high-throughput data on the patient’s specific tumor mutation and expression profiles. A remarkable case is dendritic cell-based immunotherapy, where tumor...

["Bioinformatics","Dermatology","Immunology"]
doi:10.7287/peerj.preprints.2385v1
34 downloads
198 views

Identification of appropriate reference genes (RGs) is critical to accurate data interpretation in quantitative real-time PCR (qPCR) experiments. In this study, we have utilised next generation RNA-sequencing (RNA-seq) to analyse the transcriptome of a panel of...

["Genomics","Molecular Biology","Dermatology","Oncology","Medical Genetics"]
doi:10.7287/peerj.preprints.2331v1
40 downloads
117 views

Background Global reports show that the antimicrobial-resistance of Propionibacterium acnes isolated from patients with acne vulgaris is becoming a large problem, making it necessary to find new therapeutic drugs. Methods In this study, 23 clinical isolates of...

["Microbiology","Dermatology","Infectious Diseases"]
doi:10.7287/peerj.preprints.2107v1
95 downloads
416 views

Skin diseases constitute an essential health and aesthetic problem in the elderly. The aim of the study was to evaluate the knowledge of the elderly residents of public nursing homes and participants of the University of the Third Age in Bialystok, Poland surrounding...

["Dermatology","Geriatrics","Public Health"]
doi:10.7717/peerj.2028
186 downloads
564 views

Background. Emerging research revealed the essential role of mitochondria in regulating stem/progenitor cell differentiation of neural progenitor cells, mesenchymal stem cells and other stem cells through reactive oxygen species (ROS), Notch or other signaling...

["Cell Biology","Developmental Biology","Dermatology","Pharmacology"]
doi:10.7717/peerj.1821
199 downloads
690 views

Background. Resveratrol is a natural polyphenol that exhibits anti-inflammatory effects. The aim of this study was to investigate the effects of resveratrol treatment on epithelium-derived cytokines and epithelial apoptosis in a murine model of atopic dermatitis-like...

["Allergy and Clinical Immunology","Dermatology","Immunology"]
doi:10.7717/peerj.1889
208 downloads
446 views

Background. Leprosy reactions are acute inflammatory episodes that occur mainly in the multibacillary forms of the disease. The reactions are classified as type 1 (reverse reaction) or type 2 (erythema nodosum leprosum). Leprosy-associated oxidative stress has...

["Dermatology","Infectious Diseases","Metabolic Sciences"]
doi:10.7717/peerj.1799
132 downloads
91 views

Background. Emerging researches revealed the essential role of mitochondria in regulating stem/progenitor cell differentiation of neural progenitor cells, mesenchymal stem cells and other stem cells through reactive oxygen species (ROS), Notch or other signaling...

["Cell Biology","Developmental Biology","Dermatology","Pharmacology"]
doi:10.7287/peerj.preprints.1769v1
802 downloads
8,282 views

An ever expanding body of research investigates the human microbiome in general and the skin microbiome in particular. Microbiomes vary greatly from individual to individual. Understanding the factors that account for this variation, however, has proven challenging,...

["Ecology","Evolutionary Studies","Genomics","Microbiology","Dermatology"]
doi:10.7717/peerj.1605
115 downloads
463 views

Background. Nd:YAP laser is widely used to investigate the nociceptive and pain systems, generating perpetual and laser-evoked neurophysiological responses. A major procedural concern for the use of Nd:YAP laser stimuli in experimental research is the risk of skin...

["Neuroscience","Anaesthesiology and Pain Management","Dermatology","Surgery and Surgical Specialties"]
doi:10.7717/peerj.1577
1 citation
154 downloads
572 views

Context. During the late 1990s, insecticide resistance had rendered a number of treatment products ineffective; some companies saw this as an opportunity to develop alternative types of treatment. We investigated the possibility that a surfactant-based lotion containing...

["Clinical Trials","Dermatology","Drugs and Devices","Nursing","Public Health"]
doi:10.7717/peerj.1368
1 citation
498 downloads
779 views

Tyrosinase is a well-known key enzyme in melanin biosynthesis and its inhibitors have become increasingly important because of their potential use as hypopigmenting agents. In the present study, the anti-melanogenic effect of aqueous and ethanolic extracts from...

["Biochemistry","Plant Science","Dermatology","Drugs and Devices"]
doi:10.7717/peerj.1305
479 downloads
292 views

["Anaesthesiology and Pain Management","Dermatology","Epidemiology"]
doi:10.7287/peerj.preprints.785v1
5 citations
661 downloads
1,644 views

Hair from different individuals can be distinguished by physical properties. Although some data exist on other species, examination of the individual molecular differences within the human hair shaft has not been thoroughly investigated. Shotgun proteomic analysis...

["Biochemistry","Biodiversity","Dermatology"]
doi:10.7717/peerj.506
4 citations
620 downloads
796 views

Skin and subcutaneous tissues are the origin of most common neoplasms affecting dogs, accounting for approximately one third of all tumors encountered in the species. Surgical excision is frequently the best chance for a cure; determining factors influencing the...

["Veterinary Medicine","Dermatology","Pathology"]
doi:10.7717/peerj.307

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