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Total of 355 results See all subject areas
cell biology

Background: Cardiovascular disease is a major cause of death in the western world. Regular physical activity is known to be highly beneficial for improving cardiovascular health status. Methods:The current abstract is based on the authors own data and a literature...

["Cell Biology","Diabetes and Endocrinology","Epidemiology","Kinesiology","Metabolic Sciences"]
doi:10.7287/peerj.preprints.367v1

It has been reported that the expression of TMEM65 is regulated by steroid receptor RNA activator (SRA). To date, however, the localization and function of TMEM65 remained unknown. We analyzed the intracellular localization of TMEM65. Immunoblot and immunostaining...

["Biochemistry","Cell Biology"]
doi:10.7717/peerj.349

Leishmania amazonensis is the causative agent of American cutaneous leishmaniasis, an important neglected tropical disease. Once Leishmania amazonensis is inoculated into the human host, promastigotes are exposed to the extracellular matrix (ECM) of the dermis....

["Cell Biology","Parasitology"]
doi:10.7717/peerj.317

The neurodegenerative spinocerebellar ataxia type 1 (SCA1) is caused by aggregation and misfolding of the ataxin-1 protein. While the pathology correlates with mutations that lead to expansion of a polyglutamine tract in the protein, other regions contribute to...

["Biochemistry","Cell Biology"]
doi:10.7287/peerj.preprints.259v2

Multiple cell types form specialized protein complexes, podosomes or invadopodia and collectively referred to as invadosomes, which are used by the cell to actively degrade the surrounding extracellular matrix. Due to their potential importance in both healthy...

["Bioengineering","Bioinformatics","Cell Biology","Computational Biology","Computational Science"]
doi:10.7287/peerj.preprints.320v1

We determined the effect of butyrate and other short-chain fatty acids (SCFA) on rates of lipolysis in 3T3-L1 adipocytes. Prolonged treatment with butyrate (5 mM) increased the rate of lipolysis approximately 2-3-fold. Aminobutyric acid and acetate had little or...

["Biochemistry","Cell Biology","Diabetes and Endocrinology","Metabolic Sciences"]
doi:10.7287/peerj.preprints.312v1

Tlusty's topological analysis of the genetic code suggests ecosystem changes in available metabolic free energy that predated the aerobic transition enabled a punctuated sequence of increasingly complex genetic codes and protein translators, protein folding codes,...

["Biochemistry","Cell Biology","Evolutionary Studies","Molecular Biology"]
doi:10.7287/peerj.preprints.308v1

The neurodegenerative disease spinocerebellar ataxia type 1 (SCA1) is caused by aggregation and misfolding of the ataxin-1 protein. While the pathology correlates with mutations that lead to expansion of a polyglutamine tract in the protein, other regions contribute...

["Biochemistry","Cell Biology"]
doi:10.7717/peerj.323

In Drosophila, iron is stored in the endomembrane system of cells inside a protein cavity formed by 24 ferritin subunits of two types (Fer1HCH and Fer2LCH) in a 1:1 stoichiometry. Ferritin accumulates in the midgut, nervous system, hemolymph and nephrocytes of...

["Cell Biology","Developmental Biology","Genetics"]
doi:10.7287/peerj.preprints.301v1

Following a radiation incident, preliminary dose estimates made by γ-H2AX foci analysis can supplement the early triage of casualties based on clinical symptoms. Sample processing time is important when many individuals need to be rapidly assessed. A protocol was...

["Cell Biology","Environmental Sciences","Toxicology","Radiology and Medical Imaging","Translational Medicine"]
doi:10.7717/peerj.282

The enzyme glutamine synthetase serves key roles in central nitrogen metabolism, catalyzing the biosynthesis of glutamine, as well as regulating ammonia assimilation and integrating metabolic signals to balance nitrogen use. The budding yeast enzyme was recently...

["Cell Biology","Molecular Biology"]
doi:10.7287/peerj.preprints.270v1

Background: The thickness and composition of the surface liquid lining the human lungs are maintained by a balance between epithelial secretion and absorption of ions and water. An understanding of epithelial transport pathways and the factors that regulate them...

["Bioengineering","Biophysics","Cell Biology","Molecular Biology","Respiratory Medicine"]
doi:10.7287/peerj.preprints.256v1

The minimisation of exposure of mammalian cell lines to potential microbial contaminants is handled by routine adherence to quality laboratory procedures. Mycoplasma, are capable of sustainable intracellular existence, are not v isible in light microscopy and must...

["Biochemistry","Cell Biology","Molecular Biology"]
doi:10.7287/peerj.preprints.209v2

There is a need for an genomic theoretical framework which would allow for phenomena observed in cell and also explain evolution of cellular life. The search for a genomic explanation to cancer lead to the concept of the genomic script which extends its influence...

["Bioinformatics","Cell Biology","Evolutionary Studies","Genomics","Oncology"]
doi:10.7287/peerj.preprints.126v2

Following a radiation incident, preliminary dose estimates made by γ-H2AX foci analysis can supplement the early triage of casualties based on clinical symptoms. Sample processing time is important when many individuals need to be rapidly assessed. A protocol was...

["Cell Biology","Environmental Sciences","Toxicology","Public Health","Radiology and Medical Imaging"]
doi:10.7287/peerj.preprints.163v1

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