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biophysics
10 downloads
11 views

Prions are infectious proteins where the same protein may express distinct strains. The strains are enciphered by different misfolded conformations. Strain-like phenomena have also been reported in a number of other amyloid-forming proteins. One of the features...

["Biochemistry","Biophysics"]
doi:10.7287/peerj.preprints.1101v1
29 downloads
105 views

Complex systems may be mechanistically modelled by white-box modeling with using logical deterministic individual-based cellular automata. Mathematical models of complex systems are of three types: black-box (phenomenological), white-box (mechanistic, based on...

["Biophysics","Computational Biology","Ecology","Mathematical Biology","Computational Science"]
doi:10.7717/peerj.948
25 downloads
80 views

Due to alternative splicing, the human ACTN1 gene codes for three different transcripts of α-actinin; one isoform that is expressed only in the brain and two with a more general expression pattern. The sequence difference is located to the C-terminal domains and...

["Biochemistry","Biophysics"]
doi:10.7717/peerj.944
42 downloads
159 views

Background. Datasets consisting of synthetic neural data generated with quantifiable and controlled parameters are a valuable asset in the process of testing and validating directed functional connectivity metrics. Considering the recent debate in the neuroimaging...

["Biophysics","Neuroscience","Computational Science"]
doi:10.7717/peerj.923
36 downloads
77 views

Inducing cell death by heating targeted particles shows promise in cancer treatment. Here, we aim to demonstrate the feasibility of extending the use of this technique to treat and remove vascular deposits and thrombosis. We used induction heating of macrophages,...

["Bioengineering","Biophysics","Drugs and Devices","Translational Medicine"]
doi:10.7717/peerj.929
35 downloads
26 views

The governing nonlinear steady equations for oxygen transport in a microfluidic channel are solved analytically. The Lagrange inversion theorem is used which admits complete integrable solutions in the channel. Considering a cell-rich and cell free region with...

["Biophysics","Cell Biology","Computational Biology","Mathematical Biology","Hematology"]
doi:10.7287/peerj.preprints.1003v1
34 downloads
103 views

In protein evolution, due to functional and biophysical constraints, the rates of amino acid substitution differ from site to site. Among the best predictors of site-specific rates are solvent accessibility and packing density. The packing density measure that...

["Biophysics","Computational Biology","Evolutionary Studies","Mathematical Biology"]
doi:10.7717/peerj.911
11 downloads
27 views

Due to alternative splicing the human ACTN1 gene codes for three different transcripts of α‑actinin; one isoform that is expressed only in the brain and two with a more general expression pattern. The sequence difference is located to the C-terminal domains and...

["Biochemistry","Biophysics"]
doi:10.7287/peerj.preprints.988v1
22 downloads
13 views

The steps of the DNA replication process remains to be clarified. Transcription factors are supposed to find their specific binding-sequence driven by epigenetic modifications and GpC islands. But then how can the replication machinery be able to find the promoters...

["Biophysics"]
doi:10.7287/peerj.preprints.950v1
37 downloads
199 views

Several competing aetiologies of developmental dyslexia suggest that the problems with acquiring literacy skills are causally entailed by low-level auditory and/or speech perception processes. The purpose of this study is to evaluate the diverging claims about...

["Biophysics","Developmental Biology","Neuroscience","Cognitive Disorders","Psychiatry and Psychology"]
doi:10.7717/peerj.837
49 downloads
80 views

Protein phosphorylation is one of the most important protein post-translational modifications and plays a role in numerous cellular processes including recognition, signaling and degradation. It can be studied experimentally by various methodologies, like employing...

["Bioinformatics","Biophysics","Computational Biology"]
doi:10.7287/peerj.preprints.916v1
34 downloads
78 views

Bacterial populations present in Hg-rich environments have evolved biological mechanisms to detoxify methylmercury and other organometallic mercury compounds. The most common resistance mechanism relies on the H+-assisted cleavage of the Hg-C bond of methylmercury...

["Biochemistry","Biophysics"]
doi:10.7287/peerj.preprints.909v1
43 downloads
80 views

Valveless, tubular pumps are widespread in the animal kingdom, but the mechanism by which these pumps generate fluid flow are often in dispute. Where the pumping mechanism of many organs was once described as peristalsis, other mechanisms, such as dynamic suction...

["Bioengineering","Biophysics","Computational Biology","Developmental Biology","Mathematical Biology"]
doi:10.7287/peerj.preprints.906v1
98 downloads
65 views

Many animals, including fish, can utilize both vision and the chemical senses in intra-specific communication. However, the relative influence of these sensory modalities on behavioral and physiological responses in social interactions is not well understood. The...

["Animal Behavior","Biophysics","Ecology"]
doi:10.7287/peerj.preprints.880v1
73 downloads
538 views

Noroviruses are positive-sense single-stranded RNA viruses. They encode an NS6 protease that cleaves a viral polyprotein at specific sites to produce mature viral proteins. In an earlier study we obtained crystals of murine norovirus (MNV) NS6 protease in which...

["Biochemistry","Biophysics","Molecular Biology","Virology"]
doi:10.7717/peerj.798

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