31 downloads
203 views

The microtubule depolymerising kinesin-13, MCAK, is phosphorylated at residue T537 by Cdk1. This is the only known phosphorylation site within MCAK’s motor domain. To understand the impact of phosphorylation by Cdk1 on microtubule depolymerisation activity, we...

["Biochemistry","Biophysics","Molecular Biology"]
doi:10.7717/peerj.4034
74 downloads
209 views

This work aims for modeling and simulating the metastasis of cancer, via the analogy between the cancer process and the board game Go. In the game of Go, black stones play first, could correspond to metastasis of cancer. Moreover, playing white stones on the second...

["Bioinformatics","Biophysics","Computational Biology","Mathematical Biology","Computational Science"]
doi:10.7287/peerj.preprints.3434v1
83 downloads
486 views

The expression of carbonic anhydrase (CA) IX is up-regulated in many types of solid tumors in humans under hypoxic and acidic microenvironment. Inhibition of CA IX enzymatic activity with selective inhibitors, antibodies or labeled probes has been shown to reverse...

["Biochemistry","Biophysics","Drugs and Devices"]
doi:10.7717/peerj.4068
76 downloads
815 views

In this paper, we have presented a microwave scattering analysis from multiple human head models. This study incorporates different levels of detail in the human head models and its effect on microwave scattering phenomenon. Two levels of detail are taken into...

["Bioengineering","Biophysics","Radiology and Medical Imaging","Computational Science"]
doi:10.7717/peerj.4061
78 downloads
553 views

Zebrafish is emerging as a species of choice for the study of a number of biomechanics problems, including balance development, schooling, and neuromuscular transmission. The precise quantification of the flow physics around swimming zebrafish is critical toward...

["Animal Behavior","Aquaculture, Fisheries and Fish Science","Bioengineering","Biophysics","Freshwater Biology"]
doi:10.7717/peerj.4041
85 downloads
349 views

Solanum lycopersicum, belonging to Solanaceae, is one of the commonly used model plants. The GRAS genes are transcriptional regulators, which play a significant role in plant growth and development, and the functions of several GRAS genes have been recognized,...

["Agricultural Science","Biophysics","Genomics"]
doi:10.7717/peerj.3955
253 downloads
1,395 views

Exposure to non-ionizing radiation used in wireless communication remains a contentious topic in the public mind - while the overwhelming scientific evidence to date suggests that microwave and radio frequencies used in modern communications are safe, public apprehension...

["Biophysics","Environmental Sciences","Cognitive Disorders","Oncology","Science and Medical Education"]
doi:10.7287/peerj.preprints.3355v1
157 downloads
531 views

Microbes often live in dense, dynamic, multi-species communities whose architecture and function are intimately intertwined. Imaging these complex, three-dimensional ensembles presents considerable technical challenges, however. In this review, I describe light...

["Biophysics","Microbiology"]
doi:10.7287/peerj.preprints.3135v2
40 downloads
141 views

1,4-dihydropyridines (1,4-DHP) possess important biochemical and pharmacological properties, including antioxidant and antimutagenic activities. Interaction of some 1,4-DHP with DNA was recently reported. AV-153-Na, an antimutagenic and DNA-repair-enhancing compound...

["Biophysics","Drugs and Devices"]
doi:10.7287/peerj.preprints.3317v1
54 downloads
124 views

Coarse-grained simulations enable the study of membrane proteins in the context of their native environment but require reliable parameters. The CgProt force field is assessed by comparing the potentials of mean force for sidechain insertion in a DOPC bilayer to...

["Biophysics","Computational Biology","Computational Science"]
doi:10.7287/peerj.preprints.3306v1
133 downloads
797 views

Neuron types (e.g., pyramidal cells) within one area of the brain are often considered homogeneous, despite variability in their biophysical properties. Here we review literature demonstrating variability in the electrical activity of CA1 hippocampal pyramidal...

["Biophysics","Neuroscience"]
doi:10.7717/peerj.3836
25 downloads
87 views

Scale transcends multiple levels of biological and physical organization, and is the critical factor that determines success of any scientific investigation. Specifically, the scale at which a question is posed plays a crucial role in influencing the type of experiments...

["Biochemistry","Bioengineering","Biophysics","Biotechnology","Cell Biology"]
doi:10.7287/peerj.preprints.3261v1
84 downloads
619 views

Energy buffering systems are key for homeostasis during variations in energy supply. Spiders are the most important predators for insects and therefore key in terrestrial ecosystems. From biomedical interest, spiders are important for their venoms and as a source...

["Biochemistry","Biophysics","Zoology","Allergy and Clinical Immunology"]
doi:10.7717/peerj.3787
1,226 downloads
2,334 views

Zeta potential, defined as the electric charge at the shear plane, is widely used as a proxy parameter for bacterial cell surface charge. Nonspecific adsorption of ions or polyelectrolytes onto the cell surface, however, alters the value and polarity of the measured...

["Bioengineering","Biophysics","Biotechnology","Environmental Sciences","Microbiology"]
doi:10.7287/peerj.preprints.110v7
174 downloads
1,164 views

Background The ostrich is a cursorial bird with extraordinary speed and endurance, especially in the desert, and thus is an ideal large-scale animal model for mechanic study of locomotion on granular substrate. Methods The plantar pressure distributions of ostriches...

["Animal Behavior","Bioengineering","Biophysics"]
doi:10.7717/peerj.3613

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