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biophysics
47 downloads
131 views

For this initial work, we shall focus on introducing a biological model for utilization [mainly] as a descriptive framework on which future analyses will be based. The model includes a definition of a biological systems as a composite of properties that occupy...

["Biophysics","Computational Biology","Mathematical Biology"]
doi:10.7287/peerj.preprints.1148v3
11 downloads
67 views

Synaptic exocytosis requires the assembly of syntaxin 1A and SNAP-25 on the plasma membrane and synaptobrevin 2 (VAMP2) on the vesicular membrane to bridge the two opposite membranes. It is believed that the three SNARE proteins assemble in steps along the dynamic...

["Biochemistry","Biophysics","Microbiology","Neuroscience"]
doi:10.7717/peerj.1065
9 downloads
35 views

This work follows as a response to a problem posed in a previous work: Effects of Osmolyte Infusion Interval Reductions on the Aggregate Measure of Systemic Failure: for a unicellular system. Here we propose and explore a probable solution to the posed problem...

["Biochemistry","Biophysics","Cell Biology","Mathematical Biology"]
doi:10.7287/peerj.preprints.1187v1
13 downloads
84 views

This is a companion to A Gauge model for analysis of Biological systems. Here we reconcile the gauge model with a “real” system, which in this case is a unicellular system. We address effects of changes to the frequency of osmolyte infusion, on the aggregate measure...

["Biochemistry","Biophysics","Cell Biology","Mathematical Biology","Molecular Biology"]
doi:10.7287/peerj.preprints.1163v1
27 downloads
59 views

Prions are infectious proteins where the same protein may express distinct strains. The strains are enciphered by different misfolded conformations. Strain-like phenomena have also been reported in a number of other amyloid-forming proteins. One of the features...

["Biochemistry","Biophysics"]
doi:10.7287/peerj.preprints.1101v1
53 downloads
390 views

Complex systems may be mechanistically modelled by white-box modeling with using logical deterministic individual-based cellular automata. Mathematical models of complex systems are of three types: black-box (phenomenological), white-box (mechanistic, based on...

["Biophysics","Computational Biology","Ecology","Mathematical Biology","Computational Science"]
doi:10.7717/peerj.948
53 downloads
391 views

Due to alternative splicing, the human ACTN1 gene codes for three different transcripts of α-actinin; one isoform that is expressed only in the brain and two with a more general expression pattern. The sequence difference is located to the C-terminal domains and...

["Biochemistry","Biophysics"]
doi:10.7717/peerj.944
66 downloads
429 views

Background. Datasets consisting of synthetic neural data generated with quantifiable and controlled parameters are a valuable asset in the process of testing and validating directed functional connectivity metrics. Considering the recent debate in the neuroimaging...

["Biophysics","Neuroscience","Computational Science"]
doi:10.7717/peerj.923
48 downloads
239 views

Inducing cell death by heating targeted particles shows promise in cancer treatment. Here, we aim to demonstrate the feasibility of extending the use of this technique to treat and remove vascular deposits and thrombosis. We used induction heating of macrophages,...

["Bioengineering","Biophysics","Drugs and Devices","Translational Medicine"]
doi:10.7717/peerj.929
42 downloads
76 views

The governing nonlinear steady equations for oxygen transport in a microfluidic channel are solved analytically. The Lagrange inversion theorem is used which admits complete integrable solutions in the channel. Considering a cell-rich and cell free region with...

["Biophysics","Cell Biology","Computational Biology","Mathematical Biology","Hematology"]
doi:10.7287/peerj.preprints.1003v1
53 downloads
331 views

In protein evolution, due to functional and biophysical constraints, the rates of amino acid substitution differ from site to site. Among the best predictors of site-specific rates are solvent accessibility and packing density. The packing density measure that...

["Biophysics","Computational Biology","Evolutionary Studies","Mathematical Biology"]
doi:10.7717/peerj.911
13 downloads
74 views

Due to alternative splicing the human ACTN1 gene codes for three different transcripts of α‑actinin; one isoform that is expressed only in the brain and two with a more general expression pattern. The sequence difference is located to the C-terminal domains and...

["Biochemistry","Biophysics"]
doi:10.7287/peerj.preprints.988v1
28 downloads
32 views

The steps of the DNA replication process remains to be clarified. Transcription factors are supposed to find their specific binding-sequence driven by epigenetic modifications and GpC islands. But then how can the replication machinery be able to find the promoters...

["Biophysics"]
doi:10.7287/peerj.preprints.950v1
54 downloads
487 views

Several competing aetiologies of developmental dyslexia suggest that the problems with acquiring literacy skills are causally entailed by low-level auditory and/or speech perception processes. The purpose of this study is to evaluate the diverging claims about...

["Biophysics","Developmental Biology","Neuroscience","Cognitive Disorders","Psychiatry and Psychology"]
doi:10.7717/peerj.837
63 downloads
109 views

Protein phosphorylation is one of the most important protein post-translational modifications and plays a role in numerous cellular processes including recognition, signaling and degradation. It can be studied experimentally by various methodologies, like employing...

["Bioinformatics","Biophysics","Computational Biology"]
doi:10.7287/peerj.preprints.916v1

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