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biophysics
43 downloads
218 views

We present ProCS15: A program that computes the isotropic chemical shielding values of backbone and C β atoms given a protein structure in less than a second. ProCS15 is based on around 2.35 million OPBE/6-31G(d,p)//PM6 calculations on tripeptides and small structural...

["Biophysics","Computational Biology"]
doi:10.7287/peerj.preprints.1308v2
30 downloads
302 views

Prions are infectious proteins where the same protein may express distinct strains. The strains are enciphered by different misfolded conformations. Strain-like phenomena have also been reported in a number of other amyloid-forming proteins. One of the features...

["Biochemistry","Biophysics"]
doi:10.7717/peerj.1207
25 downloads
129 views

Cells communicate with their environments using transmembrane molecular transport that is, in turn, mediated by proteins that facilitate diffusion (channels), or alternatively, translocate ions against the electrochemical gradient (pumps). Transmembrane transport...

["Biophysics","Cell Biology","Computational Biology","Neuroscience","Anatomy and Physiology"]
doi:10.7287/peerj.preprints.1312v1
19 downloads
413 views

Drag area (Ad) is a primary factor determining aerodynamic resistance during level cycling and is therefore a key determinant of level time trial performance. However, Ad has traditionally been difficult to measure. Our purpose was to determine the value of adding...

["Biophysics","Anatomy and Physiology","Kinesiology","Orthopedics"]
doi:10.7717/peerj.1144
35 downloads
102 views

Trilobites are extinct marine arthropods that dominated the faunas of the Palaeozoic. They were equipped with highly differentiated compound eyes. By contrast with all other arthropods, the lenses of these compound eyes were of pure calcite. Calcite shows photoluminescence...

["Biophysics","Paleontology"]
doi:10.7287/peerj.preprints.1288v1
32 downloads
235 views

Many animals, including fish, can utilize both vision and the chemical senses in intra-specific communication. However, the relative influence of these sensory modalities on behavioral and physiological responses in social interactions is not well understood. The...

["Animal Behavior","Biophysics","Ecology"]
doi:10.7717/peerj.1169
11 downloads
144 views

The feasibility of disrupting a tumor’s vascular structure using 210Po microspheres is investigated using standard ion and photon absorbed dose methodologies. Calculated absorbed dose profiles for 210Po alpha particles are sufficient to disrupt a tumor’s arteriole...

["Biophysics","Radiology and Medical Therapy"]
doi:10.7717/peerj.1143
19 downloads
67 views

Sustained oscillations are frequently observed in biological systems consisting of a negative feedback loop, but a mathematical model with two ordinary differential equations (ODE) that has a negative feedback loop structure fails to produce sustained oscillations....

["Biophysics","Computational Biology","Mathematical Biology"]
doi:10.7287/peerj.preprints.1272v1
79 downloads
241 views

Valveless, tubular pumps are widespread in the animal kingdom, but the mechanism by which these pumps generate fluid flow are often in dispute. Where the pumping mechanism of many organs was once described as peristalsis, other mechanisms, such as dynamic suction...

["Bioengineering","Biophysics","Computational Biology","Developmental Biology","Mathematical Biology"]
doi:10.7287/peerj.preprints.906v2
24 downloads
191 views

Bacterial populations present in Hg-rich environments have evolved biological mechanisms to detoxify methylmercury and other organometallic mercury compounds. The most common resistance mechanism relies on the H+-assisted cleavage of the Hg–C bond of methylmercury...

["Biochemistry","Biophysics"]
doi:10.7717/peerj.1127
448 downloads
439 views

Electroencephalography (EEG) signals’ interpretation is based on waveform analysis, where meaningful information should emerge from a plethora of data. Nonetheless, the continuous increase in computational power and the development of new data processing algorithms...

["Bioengineering","Bioinformatics","Biophysics","Neuroscience","Neurology"]
doi:10.7287/peerj.preprints.1265v1
31 downloads
58 views

We show here that chicken gizzard caldesmon (CaD) and its C-terminal domain (residues 636-771, CaD136) are intrinsically disordered proteins. The computational and experimental analyses of the wild type CaD136 and series of its single tryptophan mutants (W674A,...

["Biochemistry","Bioinformatics","Biophysics","Computational Biology"]
doi:10.7287/peerj.preprints.1261v1
13 downloads
24 views

This paper explores a possible underlying tenet of classical information-feed pathways (feedback and feedforward) as seen in metabolism and signaling in biological systems. We intend to determine whether information-feed pathways derive from spatial and temporal...

["Biochemistry","Bioengineering","Biophysics","Computational Biology","Molecular Biology"]
doi:10.7287/peerj.preprints.1242v1
16 downloads
87 views

This work follows as a response to a problem posed in a previous work (Jeff-Eke, 2015b). Here we propose and explore a probable solution to the posed problem of how well a cellular system can tolerate random changes to the frequency of osmolytes infused into an...

["Biochemistry","Bioengineering","Biophysics","Cell Biology","Computational Biology"]
doi:10.7287/peerj.preprints.1187v2
24 downloads
125 views

This is a companion to A Gauge model for analysis of Biological systems. Here we reconcile the gauge model with a “real” system, which in this case is a unicellular system. We address effects of infusion of free osmolytes into an intracellular space of interest,...

["Biochemistry","Bioengineering","Biophysics","Cell Biology","Mathematical Biology"]
doi:10.7287/peerj.preprints.1163v2

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