Objective Bladder cancer is a cause of considerable morbidity worldwide. Electromotive Drug Administration is a method that combines intravesical chemotherapy with local electric field application. Electroporation has been suggested among other mechanisms as having...

["Biophysics","Drugs and Devices","Oncology","Radiology and Medical Imaging","Urology"]
doi:10.7717/peerj.2309
402 downloads
516 views

History is often thought to be dull and boring – where large numbers of facts are memorized for passing exams. But the past informs the present and future, especially in delineating the context surrounding specific events that, in turn, help provide a deeper understanding...

["Biochemistry","Bioinformatics","Biophysics","Computational Biology","Computational Science"]
doi:10.7287/peerj.preprints.552v5
661 downloads
1,246 views

Zeta potential, defined as the electric charge at the shear plane, is widely used as a proxy parameter for bacteria cell surface charge. Nonspecific adsorption of ions or polyelectrolytes onto the cell surface, however, alters the value and polarity of the measured...

["Bioengineering","Biophysics","Biotechnology","Environmental Sciences","Microbiology"]
doi:10.7287/peerj.preprints.110v5
60 downloads
547 views

The PM6 semiempirical method and the dispersion and hydrogen bond-corrected PM6-D3H+ method are used together with the SMD and COSMO continuum solvation models to predict pKa values of pyridines, alcohols, phenols, benzoic acids, carboxylic acids, and phenols using...

["Biophysics","Computational Biology"]
doi:10.7717/peerj.2335
625 downloads
493 views

The past influences the present and future; for example, in computation chemistry, simplifying assumptions and approximations important in the pre-computing era remains relevant today in allowing simulation of larger systems with reasonable amount of computer time....

["Biochemistry","Bioengineering","Biophysics","Computational Biology","Computational Science"]
doi:10.7287/peerj.preprints.365v3
44 downloads
342 views

1,2-dihydro-1,2-azaborine is a structural and electronic analogue of benzene which is able to occupy benzene-binding pockets in T4 lysozyme and has been proposed as suitable arene-mimicking group for biological and pharmaceutical applications. Its applicability...

["Biochemistry","Biophysics","Drugs and Devices","Pharmacology"]
doi:10.7717/peerj.2299
53 downloads
412 views

The F1 sub-complex of ATP synthase is a biological nanomotor that converts the free energy of ATP hydrolysis into mechanical work with an astonishing efficiency of up to 100% (Kinosita et al., 2000). To probe the principal mechanics of the machine, I re-engineered...

["Biochemistry","Bioengineering","Biophysics","Synthetic Biology"]
doi:10.7717/peerj.2286
17 downloads
117 views

Bacteria surface charge derives its meaning from the cell’s environment; thus, there is no specific surface charge. Determining the surface charge of bacteria in its native environment requires measuring the proxy variable, zeta potential, using cells obtained...

["Bioengineering","Biophysics","Biotechnology","Environmental Sciences","Microbiology"]
doi:10.7287/peerj.preprints.2086v2
28 downloads
62 views

With increasing sophistication of instruments and techniques, in addition to the increment in intricacies, girth and complexities of the problems being addressed, simple methods (especially computational biology techniques) are being overlooked, replaced or phased...

["Bioinformatics","Biophysics","Computational Biology","Genomics","Microbiology"]
doi:10.7287/peerj.preprints.2296v1
14 downloads
113 views

We present a rationale and proposed approach to the modification and development of bind sites using their respective cognate ligands as template. This is in support of a plausible “instructive” role for the ligand and therefore its involvement in determination...

["Biochemistry","Bioengineering","Biophysics","Biotechnology","Mathematical Biology"]
doi:10.7287/peerj.preprints.2161v2
31 downloads
75 views

Flies use specialized photoreceptors R7 and R8 in the dorsal rim area (DRA) to detect skylight polarization. R7 and R8 form a tiered waveguide (rhabdom) with R7 on top, filtering light delivered to R8. We examine how the division of a given resource, rhabdom length,...

["Animal Behavior","Biophysics","Mathematical Biology","Neuroscience","Zoology"]
doi:10.7287/peerj.preprints.2192v1
63 downloads
516 views

Static properties of leaves with parallel venation, with particular emphasis on the genus EpipactisZinn, 1757 (Orchidaceae, Neottieae) have been modelled with coupled quasi-parallel elastic “beams.” The non-linear theory of strongly bended beams have been employed....

["Agricultural Science","Biophysics","Mathematical Biology","Plant Science"]
doi:10.7717/peerj.2165
25 downloads
85 views

Design and production of polypeptide/proteins with desired bind site properties involves utilization of the ligand of interest in selection of those bind sites that yield the desired properties from an assortment bind sites with different structures and properties....

["Biochemistry","Bioengineering","Biophysics","Biotechnology"]
doi:10.7287/peerj.preprints.2160v1
81 downloads
902 views

Mutating residues has been a common task in order to study structural properties of the protein of interest. Here, we propose and validate a simple method that allows the identification of structural determinants; i.e., residues essential for preservation of the...

["Biochemistry","Biophysics","Computational Biology","Molecular Biology"]
doi:10.7717/peerj.2136
80 downloads
311 views

Metabolomic profiling is an increasingly important method for identifying potential biomarkers in cancer cells with a view towards improved diagnosis and treatment. Nuclear magnetic resonance (NMR) provides a potentially noninvasive means to accurately characterize...

["Biophysics","Metabolic Sciences"]
doi:10.7717/peerj.2104

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