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bioinformatics
4 downloads
23 views

Metastatic cutaneous melanoma is an aggressive skin cancer with some progression-slowing treatments but no known cure. The omics data explosion has created many possible drug candidates, however filtering criteria remain challenging, and systems biology approaches...

["Bioinformatics","Computational Biology","Data Science","World Wide Web and Web Science"]
doi:10.7287/peerj.preprints.2007v1
14 downloads
149 views

Understanding the population structure and genetic diversity of plant pathogens, as well as the effect of agricultural practices on pathogen evolution, are important for disease management. Developments in molecular methods have contributed to increasing the resolution...

["Agricultural Science","Bioinformatics","Genomics","Microbiology","Taxonomy"]
doi:10.7287/peerj.preprints.1998v3
8 downloads
110 views

Development of tools to identify species, genotypes, or novel strains of invasive organisms is critical for monitoring emergence and implementing rapid response measures. Molecular markers, although critical to identifying species or genotypes, require bioinformatic...

["Agricultural Science","Bioinformatics","Microbiology","Mycology","Taxonomy"]
doi:10.7287/peerj.preprints.2005v1
1,097 downloads
2,212 views

Data is the central currency of science, but the nature of scientific data has changed dramatically with the rapid pace of technology. This change has led to the development of a wide variety of data formats, dataset sizes, data complexity, data use cases, and...

["Bioinformatics","Digital Libraries","Scientific Computing and Simulation"]
doi:10.7287/peerj.preprints.1448v2
32 downloads
296 views

The genome-wide study of epigenetic states requires the integrative analysis of histone modification ChIP-seq data. Here, we introduce an easy-to-use analytic framework to compare profiles of enrichment in histone modifications around classes of genomic elements,...

["Bioinformatics","Computational Biology","Genomics","Statistics"]
doi:10.7717/peerj.1981
15 downloads
72 views

Nascent, burgeoning, youngest, ‘connecting link between genotype and phenotype’ are just some of the phrases associated with this ‘omics’ where small molecules (metabolites with molecular weight < 2000 Daltons) are studied in biological systems, i.e., metabolomics....

["Bioinformatics","Computational Biology","Plant Science","Metabolic Sciences","Computational Science"]
doi:10.7287/peerj.preprints.2002v1
9 downloads
84 views

Background. In the early and late stages of cell reprogramming to induced pluripotent stem cells (iPSCs) ectopic expression of Oct4, Sox2, Klf4 and Myc (OSKM) aroused two peaks of transcriptional and epigenetic change respectively. However, it was relatively quiet...

["Bioinformatics","Cell Biology","Mathematical Biology","Molecular Biology","Statistics"]
doi:10.7287/peerj.preprints.1991v1
13 downloads
80 views

Biomineralization is the process by which living organisms construct hard skeletons creating complex structures that range from specialized tissues such as bone or teeth to ecosystems such as coral reefs. Biominerals are composed of both inorganic minerals and...

["Bioinformatics","Computational Biology","Evolutionary Studies","Genomics"]
doi:10.7287/peerj.preprints.1983v1
10 downloads
216 views

Access to consistent, high-quality metadata is critical to finding, understanding, and reusing scientific data. However, while there are many relevant vocabularies for the annotation of a dataset, none sufficiently captures all the necessary metadata. This prevents...

["Bioinformatics","Taxonomy","Computational Science"]
doi:10.7287/peerj.preprints.1982v1
19 downloads
92 views

Post-translational modifications of proteins expand the diversity of the proteome by several orders of magnitude and have a profound effect on several biological processes. Their detection by experimental methods is not free of limitations such as the amount of...

["Biochemistry","Bioinformatics","Computational Biology"]
doi:10.7287/peerj.preprints.1980v1
4 downloads
66 views

The chiral homogeneity of a chemical compound is the main prerequisite in safety and efficiency of drug substances and generation of single enantiomers of drug intermediates in pharmaceutical industry. Over the past several years there have been an increase wide...

["Biochemistry","Bioinformatics","Biotechnology","Computational Biology","Molecular Biology"]
doi:10.7287/peerj.preprints.1976v1
51 downloads
366 views

Background. Chromosome conformation capture, coupled with high throughput DNA sequencing in protocols like Hi-C and 3C-seq, has been proposed as viable means to generate data to resolve the genomes of microorganisms living in naturally occuring environments. Metagenomic...

["Bioinformatics","Computational Biology","Genomics","Microbiology","Computational Science"]
doi:10.7287/peerj.preprints.1974v1
17 downloads
162 views

Multilocus sequence typing (MLST) is an effective method to describe bacterial populations. Conventionally, MLST involves Polymerase Chain Reaction (PCR)amplification of housekeeping genes followed by Sanger DNA sequencing. Public Health England (PHE) is in the...

["Bioinformatics","Microbiology"]
doi:10.7287/peerj.preprints.1971v1
66 downloads
335 views

The fight against the emergence of mutant influenza strains has led to the screening of an increasing number of compounds for inhibitory activity against influenza neuraminidase. This study explores the chemical space of neuraminidase inhibitors (NAIs), which provides...

["Bioinformatics","Computational Biology","Drugs and Devices","Computational Science"]
doi:10.7717/peerj.1958
32 downloads
241 views

Bone Morphogenic Protein 2 (BMP2) is a multipurpose cytokine, important in the development of bone and cartilage, and with a role in tumour initiation and progression. BMP2 signal transduction is dependent on two distinct classes of serine/threonine kinase known...

["Bioinformatics","Cell Biology","Genomics","Drugs and Devices","Orthopedics"]
doi:10.7717/peerj.1957

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