1 download
1 view

Background Smartphones offer the hope that depression can be detected using passively collected data from the phone sensors. The aim of this study was to replicate and extend previous work using geographic location (GPS) sensors to identify depressive symptom severity....

["Bioinformatics","Psychiatry and Psychology","Public Health","Computational Science"]
doi:10.7717/peerj.2537
1 download
1 view

Antibiotics are a vital and commonly used therapeutic tool, but their use also results in profound changes in the intestinal microbiota that can, in turn, have significant health consequences. Understanding how the microbiota recovers after antibiotic treatment...

["Bioinformatics","Microbiology","Gastroenterology and Hepatology","Immunology","Nutrition"]
doi:10.7717/peerj.2518
30 downloads
272 views

Background Statistical analysis and data visualization are two crucial aspects in molecular biology and biology. For analyses that compare one dependent variable between standard (e.g., control) and one or multiple independent variables, a comprehensive yet highly...

["Biochemistry","Bioinformatics","Computational Biology","Molecular Biology","Statistics"]
doi:10.7717/peerj.2436
14 downloads
102 views

Background Abnormal proliferation of vascular smooth muscle cells (VSMC) is a major cause of cardiovascular diseases (CVDs). Many studies suggest that vascular injury triggers VSMC dedifferentiation, which results in VSMC changes from a contractile to a synthetic...

["Bioinformatics","Molecular Biology","Drugs and Devices"]
doi:10.7717/peerj.2478
12 downloads
146 views

The high cost of library preparation remains a major obstacle to sequencing large numbers of individual genomes. Illumina’s proprietary tagmentation technology allows for rapid and easy preparation of sequencing libraries, but remains prohibitively expensive for...

["Bioinformatics","Genomics","Molecular Biology"]
doi:10.7287/peerj.preprints.2475v1
26 downloads
232 views

To microbiologists, the term macroecology may conjure iconic images of wildebeests grazing in African savannahs or hummingbirds pollinating flowers in a tropical rain forest. Contrary to what the name implies, macroecology is not the ecological study of macroscopic...

["Biodiversity","Biogeography","Bioinformatics","Ecology","Microbiology"]
doi:10.7287/peerj.preprints.2478v1
73 downloads
175 views

Biomineralization is the process by which living organisms construct hard skeletons creating complex structures that range from specialized tissues such as bone or teeth to ecosystems such as coral reefs. Biominerals are composed of both inorganic minerals and...

["Bioinformatics","Computational Biology","Evolutionary Studies","Genomics"]
doi:10.7287/peerj.preprints.1983v2
51 downloads
163 views

Sharing and reusing data in research is a welcome and encouraged practice since it maximises the scientific outcomes given limited financial, material and human resources. Interdisciplinary research is considered to benefit from this practice, uniting researchers...

["Bioinformatics","Computational Biology","Data Science","Spatial and Geographic Information Systems"]
doi:10.7287/peerj.preprints.2248v3
232 downloads
518 views

Geographical Information Systems (GIS) are considered to be applications-led technology. Consequently, geographic information scientists commonly find themselves as guest in host disciplines in order to best exploit spatial analysis tools and methods, appropriately...

["Bioinformatics","Computational Biology","Spatial and Geographic Information Systems"]
doi:10.7287/peerj.preprints.1721v2
14 downloads
111 views

Annually, half of all plant-derived carbon is added to soil where it is microbially respired to CO2. However, understanding of the microbiology of this process is limited because most culture-independent methods cannot link metabolic processes to the organisms...

["Bioinformatics","Environmental Sciences","Genomics","Microbiology","Soil Science"]
doi:10.7287/peerj.preprints.2473v1
59 downloads
254 views

Background Meningitis is a major cause of mortality in tuberculosis (TB). It is not clear what factors promote central nervous system invasion and pathology but it has been reported that certain strains of Mycobacterium tuberculosis (Mtb) might have genetic traits...

["Bioinformatics","Genomics","Microbiology"]
doi:10.7717/peerj.2484
21 downloads
203 views

Unique Molecular Identifiers (UMIs) have been incorporated into RNA-Seq experiments to overcome issues with abundance estimation from samples that may have many PCR amplification cycles. However, the use of UMIs in many different types of sequencing experiments...

["Bioinformatics","Genetics","Genomics"]
doi:10.7287/peerj.preprints.2465v1
54 downloads
180 views

Forest trees cover just over 30% of the earth's surface and are studied by researchers around the world for both their conservation and economic value. With the onset of high throughput technologies, tremendous phenotypic and genomic data sets have been generated...

["Bioinformatics","Data Mining and Machine Learning","Databases"]
doi:10.7287/peerj.preprints.2345v4
296 downloads
1,712 views

Background The bacterial 16S rRNA gene has historically been used in defining bacterial taxonomy and phylogeny. However, there are currently no high-throughput methods to sequence full-length 16S rRNA genes present in a sample with precision. Results We describe...

["Bioinformatics","Ecology","Microbiology"]
doi:10.7717/peerj.2492
32 downloads
231 views

Across independent cancer genomes it has been observed that some sites have been recurrently hit by single nucleotide variants (SNVs). Such recurrently hit sites might be either (i) drivers of cancer that are postively selected during oncogenesis, (ii) due to mutation...

["Bioinformatics","Computational Biology","Genetics","Genomics","Computational Science"]
doi:10.7717/peerj.2391

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