17 downloads
92 views

Myogenesis is a complicated process, which is regulated by numerous regulators. MicroRNAs (miRNAs) are conserved non-coding RNAs of ~22 nucleotides, which regulate post-transcriptional gene expression in many physiological and pathophysiological processes. Recent...

["Agricultural Science","Biochemistry","Cell Biology"]
doi:10.7287/peerj.preprints.3454v1
49 downloads
777 views

Background Carbonic anhydrases (CAs) are ubiquitous, essential enzymes which catalyze the conversion of carbon dioxide and water to bicarbonate and H+ ions. Vertebrate genomes generally contain gene loci for 15–21 different CA isoforms, three of which are enzymatically...

["Biochemistry","Bioinformatics","Evolutionary Studies"]
doi:10.7717/peerj.4128
25 downloads
192 views

The microtubule depolymerising kinesin-13, MCAK, is phosphorylated at residue T537 by Cdk1. This is the only known phosphorylation site within MCAK’s motor domain. To understand the impact of phosphorylation by Cdk1 on microtubule depolymerisation activity, we...

["Biochemistry","Biophysics","Molecular Biology"]
doi:10.7717/peerj.4034
57 downloads
157 views

Among copepods, which are the most abundant animals on Earth, the genus Oithona is described as one of the most important and plays a major role in the marine food chain and biogeochemical cycles, particularly through the excretion of chitin-coated fecal pellets....

["Biochemistry","Marine Biology","Aquatic and Marine Chemistry","Biogeochemistry"]
doi:10.7287/peerj.preprints.3447v1
30 downloads
204 views

A striking and unexpected biochemical phenotype was found in an insertion mutant line in the model plant Arabidopsis thaliana. One of two investigated insertion mutant lines in the gene encoding the phosphate transporter PHT4;1 demonstrated a prominent loss of...

["Biochemistry","Genetics","Plant Science"]
doi:10.7717/peerj.4134
77 downloads
480 views

The expression of carbonic anhydrase (CA) IX is up-regulated in many types of solid tumors in humans under hypoxic and acidic microenvironment. Inhibition of CA IX enzymatic activity with selective inhibitors, antibodies or labeled probes has been shown to reverse...

["Biochemistry","Biophysics","Drugs and Devices"]
doi:10.7717/peerj.4068
37 downloads
78 views

Trace contaminant removal is of contemporary concern in drinking water and wastewater treatment, given increasing evidence of potential toxicity of various heavy metals and metalloids in water at parts per billion (ppb) concentration levels. Currently, only high...

["Biochemistry","Bioengineering","Biotechnology","Aquatic and Marine Chemistry","Environmental Contamination and Remediation"]
doi:10.7287/peerj.preprints.3423v1
141 downloads
217 views

We propose a new hypothesis about the physical-chemical mechanisms of nerve conduction in myelinated nerves, tending to bridge the theoretical gap existing to date between the basic neuronal activity and its adaptation to myelination. All the considerations imply...

["Biochemistry","Neuroscience","Neurology"]
doi:10.7287/peerj.preprints.3409v1
23 downloads
92 views

Arbutin (p-hydroxyphenyl-β-D-glucopyranoside), a well-known tyrosinase inhibitor, has been widely used as a cosmetic whitening agent. Although its natural role is to scavenge free radicals within cells, it has also exhibited useful activities for the treatment...

["Animal Behavior","Biochemistry","Molecular Biology"]
doi:10.7287/peerj.preprints.3405v1
55 downloads
206 views

The wood frog (Rana sylvatica) can endure freezing of up to 65% of total body water during winter. When frozen, wood frogs enter a dormant state characterized by a cessation of vital functions (i.e., no heartbeat, blood circulation, breathing, brain activity, or...

["Biochemistry","Molecular Biology"]
doi:10.7717/peerj.4014
38 downloads
297 views

Robotic labs, in which experiments are carried out entirely by robots, have the potential to provide a reproducible and transparent foundation for performing basic biomedical laboratory experiments. In this article, we investigate whether these labs could be applicable...

["Biochemistry","Science Policy","Computational Science"]
doi:10.7717/peerj.3997
78 downloads
388 views

Background Deficiency of available forms of phosphorus is common in most soils and causes reduction of crop plants growth and yield. Recently, model plants responses to phosphate (Pi) deficiency have been intensively studied. However, acclimation mechanisms of...

["Agricultural Science","Biochemistry","Environmental Sciences","Plant Science","Soil Science"]
doi:10.7717/peerj.3989
17 downloads
95 views

While biochemistry evidently affects the growth rate of cells, many biochemists routinely ignore population variation, just like population geneticists usually ignore causal details of biochemistry that underpin a change in growth rate caused by a mutation. A true...

["Biochemistry","Cell Biology","Computational Biology","Oncology","Computational Science"]
doi:10.7287/peerj.preprints.3371v1
136 downloads
497 views

Clinical evidence points to neuroprotective effects of smoking in Parkinson’s disease (PD), but the molecular mechanisms remain unclear. We investigated the pharmacological pathways involved in these neuroprotective effects, which could provide novel ideas for...

["Biochemistry","Molecular Biology","Neuroscience","Neurology","Pharmacology"]
doi:10.7717/peerj.3933
136 downloads
378 views

Increased levels of long noncoding RNA H19 (H19) have been observed in many inflammatory and organ fibrosis diseases including ulcerative colitis, osteoarthritis, liver fibrosis, renal fibrosis and pulmonary fibrosis. However, the role of H19 in bovine mastitis...

["Biochemistry","Cell Biology","Veterinary Medicine"]
doi:10.7717/peerj.3950

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