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Total of 128 results See all subject areas
oncology

Background. An “In Silico 2D/3D Conformer Screening” for structural similar antitumor substances to Curcumin was carried out and the novel antrachinone BTB14431 was found. Emodin, contained in several Chinese medical plants and BTB14431 are known to be potential...

["Drugs and Devices","Oncology","Surgery and Surgical Specialties"]
doi:10.7287/peerj.preprints.304v1

Background. The impact of head and neck cancer (HNC) in long-term survivors differs widely among individuals, and a significant number of them suffer from the negative effects of disease, whereas others report significant positive effect. This systematic review...

["Oncology","Psychiatry and Psychology"]
doi:10.7717/peerj.256

There is a need for an genomic theoretical framework which would allow for phenomena observed in cell and also explain evolution of cellular life. The search for a genomic explanation to cancer lead to the concept of the genomic script which extends its influence...

["Bioinformatics","Cell Biology","Evolutionary Studies","Genomics","Oncology"]
doi:10.7287/peerj.preprints.126v2

Mammary gland tumors represent 42% of all tumors in the bitch. Although there are numerous studies about disease development and progression, some questions remain concerning the surgical treatment. Many surgical techniques may be used for the treatment of canine...

["Veterinary Medicine","Oncology","Surgery and Surgical Specialties"]
doi:10.7287/peerj.preprints.143v1

Background: In literature-based meta-analyses of cancer prognostic studies, methods for extracting summary statistics from published reports have been extensively employed. However, no assessment of the magnitude of bias produced by these methods or comparison...

["Epidemiology","Evidence Based Medicine","Oncology","Statistics"]
doi:10.7287/peerj.preprints.142v1

Glioblastoma multiforme is a grade IV astrocytoma arising de novo or progressing from lower grade II and III gliomas. Currently the etiology of glioma and prediction of disease progression are unknown. Recent epidemiological studies have suggested that hormonal...

["Clinical Trials","Gynecology and Obstetrics","Neurology","Oncology","Translational Medicine"]
doi:10.7287/peerj.preprints.134v1

Exosomes are nanosized (30–100 nm) membrane vesicles secreted by most cell types. Exosomes have been found to contain various RNA species including miRNA, mRNA and long non-protein coding RNAs. A number of cancer cells produce elevated levels of exosomes. Because...

["Bioinformatics","Cell Biology","Computational Biology","Genetics","Oncology"]
doi:10.7717/peerj.201

Castration-resistant prostate cancer (CRPC) expresses high levels of the anti-apoptotic proteins Bcl-2, Bcl-xL and Mcl-1, resulting in resistance to apoptosis and association with poor prognosis. Docetaxel, an antimitotic drug that is the first-line treatment strategy...

["Molecular Biology","Oncology"]
doi:10.7717/peerj.144

Exosomes are nanosized (30-100 nm) membrane vesicles secreted by most cell types. Exosomes have been found to contain various RNA species including miRNA, mRNA and long non-protein coding RNAs. A number of cancer cells produce elevated levels of exosomes. Because...

["Bioinformatics","Cell Biology","Computational Biology","Genetics","Oncology"]
doi:10.7287/peerj.preprints.56v1

Prostate cancer is a prevalent age-related disease in North America, accounting for about 15% of all diagnosed cancers. We have previously identified lithocholic acid (LCA) as a potential chemotherapeutic compound that selectively kills neuroblastoma cells while...

["Toxicology","Oncology","Pharmacology"]
doi:10.7717/peerj.122

A 68 year old male with a history of classical Kaposi's sarcoma (KS) and precursor T-cell acute lymphoblastic leukemia (ALL) received an allogenic stem cell transplant from an unrelated donor to treat his ALL. He developed acute graft-vs.-host-disease (GVHD) which...

["Immunology","Infectious Diseases","Nephrology","Oncology","Science and Medical Education"]
doi:10.7287/peerj.preprints.48v1

Somatic mutations in GNAQ gene were described as being the main oncogenic activation in uveal melanomas, whereas mutations in BRAF gene have been described as a key genetic alteration that contributes to skin melanoma development. We have previously reported differential...

["Cell Biology","Molecular Biology","Oncology"]
doi:10.7717/peerj.104

Since the discovery of tumour initiating cells (TICs) in solid tumours, studies focussing on their role in cancer initiation and progression have abounded. The biological interrogation of these cells continues to yield volumes of information on their pro-tumourigenic...

["Mathematical Biology","Oncology","Computational Science"]
doi:10.7287/peerj.preprints.17

Mus spretus mice are highly resistant to several types of cancer compared to Mus musculus mice. To determine whether differences in microRNA (miRNA) expression account for some of the differences in observed skin cancer susceptibility between the strains, we performed...

["Genetics","Molecular Biology","Oncology"]
doi:10.7717/peerj.68

The anti-CD20 monoclonal antibody, rituximab, provides a significant therapeutic benefit for patients with B-cell disorders. However, response to therapy varies and relapses are common, so an understanding of both inherited and acquired rituximab resistance is...

["Cell Biology","Molecular Biology","Hematology","Immunology","Oncology"]
doi:10.7717/peerj.31

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