Peer-reviewed Articles

Drug repositioning (i.e., drug repurposing) is the process of discovering new uses for marketed drugs. Historically, such discoveries were serendipitous. However, the rapid growth in electronic clinical data and text mining tools makes it feasible to systematically...

["Bioinformatics","Clinical Trials","Drugs and Devices","Oncology","Statistics"]
doi:10.7717/peerj.3154

The wood-feeding cockroach Cryptocercus punctulatus Scudder (Blattodea: Cryptocercidae) is an important member of the dead wood (saproxylic) community in montane forests of the southeastern United States. However, its population biology remains poorly understood....

["Entomology","Genetics","Zoology"]
doi:10.7717/peerj.3127

In a series of experiments, seeds from a temperate seagrass species, Zostera nigricaulis collected in Port Phillip Bay, Victoria, Australia were exposed to a range of salinities (20 PSU pulse/no pulse, 25 PSU, 30 PSU, 35 PSU), temperatures (13 °C, 17 °C, 22 °C),...

["Marine Biology","Plant Science"]
doi:10.7717/peerj.3114

The spotted wing Drosophila, Drosophila suzukii, is a new pest in Europe and America which causes severe damages, mostly to stone fruit crops. Temperature and humidity are among the most important abiotic factors governing insect development and fitness. In many...

["Ecology","Entomology","Environmental Sciences"]
doi:10.7717/peerj.3112

The literature indicates the best vibration positions and frequencies on the human body where tactile information is transmitted. However, there is a lack of knowledge about how to combine tactile stimuli for navigation. The aim of this study is to compare different...

["Kinesiology","Psychiatry and Psychology","Human-Computer Interaction"]
doi:10.7717/peerj.3082

Eutrophic aquatic habitats are characterized by the proliferation of vegetation leading to a large standing biomass that upon decomposition may create hypoxic (low-oxygen) conditions. This is indeed the case in nutrient impacted estuaries of Prince Edward Island,...

["Animal Behaviour","Ecology","Environmental Sciences","Marine Biology"]
doi:10.7717/peerj.3080

Rare hybridisations between deeply divergent animal species have been reported for decades in a wide range of taxa, but have often remained unexplained, mainly considered chance events and reported as anecdotal. Here, we combine field observations with long-term...

["Ecology","Evolutionary Studies","Zoology"]
doi:10.7717/peerj.3072

Background The present-day amphibian and reptile fauna of Western Siberia are the least diverse of the Palaearctic Realm, as a consequence of the unfavourable climatic conditions that predominate in this region. The origin and emergence of these herpetofaunal groups...

["Biodiversity","Biogeography","Paleontology","Taxonomy","Zoology"]
doi:10.7717/peerj.3025
8 downloads
94 views

Increases in ocean temperature due to climate change are predicted to change the behaviors of marine invertebrates. Altered behaviors of keystone ecosystem engineers such as echinoderms will have consequences for the fitness of individuals, which are expected to...

["Animal Behavior","Ecology","Marine Biology"]
doi:10.7717/peerj.3122
12 downloads
166 views

Objective The purpose of this study was to assess the effects of age, body condition score (BCS) and muscle condition score (MCS) on indirect radial and coccygeal Doppler systolic arterial blood pressure (SAP) measurements in dogs. Methods Sixty-two privately-owned...

["Veterinary Medicine","Internal Medicine"]
doi:10.7717/peerj.3101
63 downloads
151 views

This study explores how curvature in the quokka femur may help to reduce bending strain during locomotion. The quokka is a small wallaby, but the curvature of the femur and the muscles active during stance phase are similar to most quadrupedal mammals. Our hypothesis...

["Computational Biology","Evolutionary Studies","Zoology"]
doi:10.7717/peerj.3100
31 downloads
224 views

DNA metabarcoding, the PCR-based profiling of natural communities, is becoming the method of choice for biodiversity monitoring because it circumvents some of the limitations inherent to traditional ecological surveys. However, potential sources of bias that can...

["Ecology","Molecular Biology"]
doi:10.7717/peerj.3006
20 downloads
140 views

Background and Objective The Korean version of the EQ-5D-Y was launched in 2015 by the EuroQol group. Currently, there is no HRQOL data obtained by using the EQ-5D-Y in Korea. This study aimed to measure health-related quality of life of Korean elementary school...

["Epidemiology","Global Health","Health Policy","Pediatrics","Public Health"]
doi:10.7717/peerj.3115
25 downloads
146 views

Apoptosis of lymphocytes is associated with immunosuppression and poor prognosis in sepsis. Our previous report showed that histones, nuclear proteins released from damaged or dying cells in sepsis, can mediate lymphocyte apoptosis via mitochondria damage. Grape...

["Cell Biology","Immunology","Pharmacology"]
doi:10.7717/peerj.3108
28 downloads
137 views

Background While evidence highlights the detrimental health consequences of adverse working conditions, effect sizes vary by the stressor examined. In this study, we aimed to explore the differential effects various constellations of job demands have on prevalent...

["Psychiatry and Psychology","Public Health"]
doi:10.7717/peerj.3106

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