Peer-reviewed Articles

123 downloads
358 views

Background Histone lysine methyltransferases (HMTs), a category of enzymes, play essential roles in regulating transcription, cellular differentiation, and chromatin construction. The genomic landscape and clinical significance of HMTs in renal cell carcinoma (RCC)...

["Genetics","Oncology","Urology"]
doi:10.7717/peerj.6396
125 downloads
432 views

Background Increasing evidence has demonstrated that long non-coding RNAs (lncRNAs) play an important role in the competitive endogenous RNA (ceRNA) networks in that they regulate protein-coding gene expression by sponging microRNAs (miRNAs). However, the understanding...

["Bioinformatics","Dentistry","Oncology"]
doi:10.7717/peerj.6397
82 downloads
386 views

Colorectal cancer (CRC), also known as colon cancer, is the third most common form of cancer worldwide in men and the second in women and is characterized by several genetic alterations, among them the expression of several genes. 1,2-dimethylhydrazine (DMH) and...

["Food Science and Technology","Molecular Biology","Nutrition","Oncology"]
doi:10.7717/peerj.6372
78 downloads
433 views

Early detection and prediction of prognosis and treatment responses are all the keys in improving survival of ovarian cancer patients. This study profiled an ovarian cancer progression model to identify prognostic biomarkers for ovarian cancer patients. Mouse ovarian...

["Bioinformatics","Cell Biology","Oncology"]
doi:10.7717/peerj.6301
76 downloads
464 views

ZBTB38 belongs to the zinc finger protein family and contains the typical BTB domains. As a transcription factor, ZBTB38 is involved in cell regulation, proliferation and apoptosis, whereas, functional deficiency of ZBTB38 induces the human neuroblastoma (NB) cell...

["Bioinformatics","Cell Biology","Genomics","Nephrology","Oncology"]
doi:10.7717/peerj.6352
65 downloads
359 views

Background Monopolar spindle 1 (Mps1/TTK) is an apical dual-specificity protein kinase in the spindle assembly checkpoint (SAC) that guarantees accurate segregation of chromosomes during mitosis. High levels of Mps1 are found in various types of human malignancies,...

["Computational Biology","Oncology"]
doi:10.7717/peerj.6299
99 downloads
399 views

The fight against cancer has been a never-ending battle. Limitations of conventional therapies include lack of selectivity, poor penetration and highly toxic to the host. Using genetically modified bacteria as a tumour therapy agent has gained the interest of scientist...

["Bioengineering","Biotechnology","Microbiology","Molecular Biology","Oncology"]
doi:10.7717/peerj.5989
60 downloads
310 views

Background Cyclin A overexpression is found in a variety of human tumors and correlates with unfavorable outcome. We analyzed immunohistochemical expression of cyclin A in Wilms tumor (WT) in relation to clinicopathological characteristics, preoperative chemotherapy...

["Nephrology","Oncology","Pathology","Pediatrics","Urology"]
doi:10.7717/peerj.6212
151 downloads
488 views

Background Breast cancer is the most common type of cancer among females. Hypoxia mediates cancer hallmarks and results from reduced oxygen level due to irregularities in tumor vascularization or when the tumor size prevents oxygen diffusion and triggers angiogenesis...

["Cell Biology","Oncology","Pharmacology"]
doi:10.7717/peerj.5990
94 downloads
385 views

Pleurotus ferulae is an edible and medicinal mushroom with various bioactivities. Here, the ethanol extracts of wild and cultivated P. ferulae (PFEE-W and PFEE-C) and their subfractions including petroleum ether (Pe-W/Pe-C), ethyl acetate (Ea-W/Ea-C) and n-butanol...

["Biochemistry","Cell Biology","Food Science and Technology","Oncology"]
doi:10.7717/peerj.6097
140 downloads
517 views

Objective This study aims to reveal the regulation network of lncRNAs-miRNAs-mRNA in endometrial carcinoma (EC), to investigate the underlying mechanisms of EC occurrence and progression, to screen prognostic biomarkers. Methods RNA-seq and miRNA-seq data of endometrial...

["Gynecology and Obstetrics","Oncology"]
doi:10.7717/peerj.6091
79 downloads
440 views

Background Colorectal cancer remains a serious public health problem due to the poor prognosis. In the present study, we attempted to develop and validate a prognostic signature to predict the individual mortality risk in colorectal cancer patients. Materials and...

["Bioinformatics","Molecular Biology","Gastroenterology and Hepatology","Oncology"]
doi:10.7717/peerj.6061
105 downloads
457 views

Background DNA repair is essential to counteract damage to DNA induced by endo- and exogenous factors, to maintain genome stability. However, challenges to the faithful discrimination between damaged and non-damaged DNA strands do exist, such as mismatched pairs...

["Biochemistry","Cell Biology","Genetics","Molecular Biology","Oncology"]
doi:10.7717/peerj.6029
224 downloads
922 views

Background Bladder cancer is a malignant tumor in the urinary system with high mortality and recurrence rates. However, the causes and recurrence mechanism of bladder cancer are not fully understood. In this study, we used integrated bioinformatics to screen for...

["Bioinformatics","Oncology","Data Mining and Machine Learning"]
doi:10.7717/peerj.6036
192 downloads
993 views

Patient-derived xenograft (PDX) models are increasingly being used in oncology drug development because they offer greater predictive value than traditional cell line models. Using novel tools to critique model validity and reliability we performed a systematic...

["Oncology","Translational Medicine"]
doi:10.7717/peerj.5981

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