Peer-reviewed Articles

Microalgae, eukaryotic unicellular plants, are increasing in demand due to their use as nutraceutical and food supplements. They consisted different kinds of biologically active components such as polysaccharides. On the other hand, cancer is the leading cause...

["Biochemistry","Evidence Based Medicine","Oncology"]
doi:10.7717/peerj.6409
57 downloads
111 views

Objective This study was performed to identify a reasonable cutoff age for defining older patients with colorectal cancer (CRC) and to examine whether old age was related with increased colorectal cancer-specific death (CSD) and poor colorectal cancer-specific...

["Gastroenterology and Hepatology","Geriatrics","Oncology"]
doi:10.7717/peerj.6350
44 downloads
125 views

Background Sequencing studies across multiple cancers continue to reveal mutations and genes involved in the pathobiology of these cancers. Exome sequencing of oral cancers, a subset of Head and Neck Squamous cell Carcinomas (HNSCs) common among tobacco-chewing...

["Bioinformatics","Genomics","Immunology","Oncology"]
doi:10.7717/peerj.6402
68 downloads
381 views

Background Financial conflicts of interest (FCOI) are known to be prevalent in medicine. Authorship of pivotal trials reap non-financial benefits including publication productivity that can be used for assessment of tenure positions and promotion. The purpose of...

["Clinical Trials","Oncology","Ethical Issues"]
doi:10.7717/peerj.6423
119 downloads
220 views

The hypoxic tumor microenvironment is the major contributor of chemotherapy resistance in solid tumors. One of the key regulators of hypoxic responses within the cell is the hypoxia inducible factor-1α (HIF-1α) that is involved in transcription of genes promoting...

["Biotechnology","Oncology"]
doi:10.7717/peerj.6309
56 downloads
245 views

Background Alcohol-related hepatocellular carcinoma (HCC) was reported to be diagnosed at a later stage, but the mechanism was unknown. This study aimed to identify special key genes (SKGs) during alcohol-related HCC development and progression. Methods The mRNA...

["Bioinformatics","Gastroenterology and Hepatology","Global Health","Oncology"]
doi:10.7717/peerj.6375
68 downloads
150 views

Background Histone lysine methyltransferases (HMTs), a category of enzymes, play essential roles in regulating transcription, cellular differentiation, and chromatin construction. The genomic landscape and clinical significance of HMTs in renal cell carcinoma (RCC)...

["Genetics","Oncology","Urology"]
doi:10.7717/peerj.6396
63 downloads
150 views

Background Increasing evidence has demonstrated that long non-coding RNAs (lncRNAs) play an important role in the competitive endogenous RNA (ceRNA) networks in that they regulate protein-coding gene expression by sponging microRNAs (miRNAs). However, the understanding...

["Bioinformatics","Dentistry","Oncology"]
doi:10.7717/peerj.6397
38 downloads
211 views

Colorectal cancer (CRC), also known as colon cancer, is the third most common form of cancer worldwide in men and the second in women and is characterized by several genetic alterations, among them the expression of several genes. 1,2-dimethylhydrazine (DMH) and...

["Food Science and Technology","Molecular Biology","Nutrition","Oncology"]
doi:10.7717/peerj.6372
47 downloads
268 views

Early detection and prediction of prognosis and treatment responses are all the keys in improving survival of ovarian cancer patients. This study profiled an ovarian cancer progression model to identify prognostic biomarkers for ovarian cancer patients. Mouse ovarian...

["Bioinformatics","Cell Biology","Oncology"]
doi:10.7717/peerj.6301
35 downloads
283 views

ZBTB38 belongs to the zinc finger protein family and contains the typical BTB domains. As a transcription factor, ZBTB38 is involved in cell regulation, proliferation and apoptosis, whereas, functional deficiency of ZBTB38 induces the human neuroblastoma (NB) cell...

["Bioinformatics","Cell Biology","Genomics","Nephrology","Oncology"]
doi:10.7717/peerj.6352
40 downloads
203 views

Background Monopolar spindle 1 (Mps1/TTK) is an apical dual-specificity protein kinase in the spindle assembly checkpoint (SAC) that guarantees accurate segregation of chromosomes during mitosis. High levels of Mps1 are found in various types of human malignancies,...

["Computational Biology","Oncology"]
doi:10.7717/peerj.6299
55 downloads
253 views

The fight against cancer has been a never-ending battle. Limitations of conventional therapies include lack of selectivity, poor penetration and highly toxic to the host. Using genetically modified bacteria as a tumour therapy agent has gained the interest of scientist...

["Bioengineering","Biotechnology","Microbiology","Molecular Biology","Oncology"]
doi:10.7717/peerj.5989
41 downloads
181 views

Background Cyclin A overexpression is found in a variety of human tumors and correlates with unfavorable outcome. We analyzed immunohistochemical expression of cyclin A in Wilms tumor (WT) in relation to clinicopathological characteristics, preoperative chemotherapy...

["Nephrology","Oncology","Pathology","Pediatrics","Urology"]
doi:10.7717/peerj.6212
95 downloads
283 views

Background Breast cancer is the most common type of cancer among females. Hypoxia mediates cancer hallmarks and results from reduced oxygen level due to irregularities in tumor vascularization or when the tumor size prevents oxygen diffusion and triggers angiogenesis...

["Cell Biology","Oncology","Pharmacology"]
doi:10.7717/peerj.5990

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