Peer-reviewed Articles

45 downloads
150 views

Background Sequencing studies across multiple cancers continue to reveal mutations and genes involved in the pathobiology of these cancers. Exome sequencing of oral cancers, a subset of Head and Neck Squamous cell Carcinomas (HNSCs) common among tobacco-chewing...

["Bioinformatics","Genomics","Immunology","Oncology"]
doi:10.7717/peerj.6402
130 downloads
72 views

Background Most renal allograft recipients reach a stable immune state (neither rejection nor infection) after transplantation. However, the detailed distribution of overall T lymphocyte subsets in the peripheral blood of these immune-stable renal transplant recipients...

["Immunology","Urology"]
doi:10.7717/peerj.6417
42 downloads
222 views

Persistent colonization of the avian reproductive tract by Salmonella enterica serovar Enteritidis (SE) negatively affects egg production and contaminates the egg. The immune function of the ovary and oviduct is essential for protection from infection and for the...

["Agricultural Science","Microbiology","Veterinary Medicine","Immunology"]
doi:10.7717/peerj.6359
57 downloads
230 views

In Vietnam, vaccination has played a crucial role in the national strategy for the prevention and control of H5 highly pathogenic avian influenza (HPAI). This study aimed to evaluate antibody responses of immunologically naïve domestic ducks to H5N1 avian influenza...

["Veterinary Medicine","Immunology"]
doi:10.7717/peerj.6268
129 downloads
447 views

Several studies have shown that epitope vaccines exhibit substantial advantages over conventional vaccines. However, epitope vaccines are associated with limited immunity, which can be overcome by conjugating antigenic epitopes with built-in adjuvants (e.g., some...

["Biotechnology","Veterinary Medicine","Immunology"]
doi:10.7717/peerj.6185
79 downloads
252 views

Background New reagents have emerged allowing researchers to assess a growing number of vaccine-associated immune parameters. Multiplex immunoassay(s) are emerging as efficient high-throughput assays in malaria serology. Currently, commercial vendors market several...

["Global Health","Immunology","Infectious Diseases","Translational Medicine"]
doi:10.7717/peerj.6120
81 downloads
190 views

Background Previous studies have shown that the adaptive immunity function of T cells in disease states correlates with CD3 surface expression closely. During routine assessment of TBNK subsets in peripheral blood of pediatric patients by flow cytometry, we noticed...

["Immunology","Infectious Diseases","Pediatrics"]
doi:10.7717/peerj.6114
64 downloads
306 views

Background Only few aerobic exercise intervention trials specifically targeting cognitive functioning have been performed in multiple sclerosis. Objective and Methods This randomized controlled trial with 34 patients in the intervention group (IG) (mean: 38.2 years...

["Clinical Trials","Immunology","Neurology","Psychiatry and Psychology"]
doi:10.7717/peerj.6037
79 downloads
422 views

The parasite Toxoplasma gondii causes an opportunistic infection, that is, particularly severe in immunocompromised patients, infants, and neonates. Current antiparasitic drugs are teratogenic and cause hypersensitivity-based toxic side effects especially during...

["Biotechnology","Molecular Biology","Parasitology","Plant Science","Immunology"]
doi:10.7717/peerj.5780
73 downloads
331 views

Background Dry eye disease (DED), a chronic ocular disease, is associated with numerous medical issues, including asthma. However, studies on these associations are limited. In this study, we investigated the incidence of DED among patients with asthma and its...

["Allergy and Clinical Immunology","Immunology"]
doi:10.7717/peerj.5941
60 downloads
265 views

Multiplex bead assays are an extension of the commonly used sandwich ELISA. The advantage over ELISA is that they make simultaneous evaluation of several analytes possible. Several commercial assay systems, where the beads are acquired on a standard flow cytometer,...

["Immunology","Computational Science"]
doi:10.7717/peerj.5794
95 downloads
516 views

Background Osteoclast differentiation in the inflamed synovium of rheumatoid arthritis (RA) affected joints leads to the formation of bone lesions. Reconstruction and analysis of protein interaction networks underlying specific disease phenotypes are essential...

["Bioinformatics","Computational Biology","Genomics","Immunology","Rheumatology"]
doi:10.7717/peerj.5743
91 downloads
394 views

Objective The benefits of IL-35 treatment have been verified in multiple animal models of diseases, while its influence on T cells immunity under normal condition still needs to be elucidated. The present study was designed to investigate the effects modulating...

["Immunology","Translational Medicine"]
doi:10.7717/peerj.5638
117 downloads
895 views

Background Silver nanoparticles (AgNPs) have been widely used in many commercial products due to their excellent antibacterial ability. The AgNPs are released into the environment, gradually accumulate in the ocean, and may affect animals at high trophic levels,...

["Toxicology","Veterinary Medicine","Immunology","Ecotoxicology","Environmental Contamination and Remediation"]
doi:10.7717/peerj.5432
109 downloads
494 views

Background Minimal change disease (MCD) is a form of idiopathic nephrotic syndrome. Compared to children, adult-onset MCD patients are reported to have delayed responses to glucocorticoid treatment. Several studies of children have suggested detecting urinary CD80...

["Immunology","Nephrology"]
doi:10.7717/peerj.5400

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