Peer-reviewed Articles

122 downloads
396 views

Background Transcription factors and microRNAs play a critical role in regulating the gene expression in normal physiology and pathological conditions. Many bioinformatics tools were built to predict and identify transcription factor and microRNA targets and their...

["Cell Biology","Computational Biology","Molecular Biology"]
doi:10.7717/peerj.6509
149 downloads
437 views

Background Solanum nigrum (black nightshade; S. nigrum), a member of family Solanaceae, has been endowed with a heterogeneous array of secondary metabolites of which the steroidal glycoalkaloids (SGAs) and steroidal saponins (SS) have vast potential to serve as...

["Biochemistry","Bioinformatics","Cell Biology","Computational Biology","Plant Science"]
doi:10.7717/peerj.6012
1 citation
373 downloads
2,343 views

Background Real-time quantitative PCR (qPCR) is a broadly used technique in the biomedical research. Currently, few different analysis models are used to determine the quality of data and to quantify the mRNA level across the experimental conditions. Methods We...

["Bioinformatics","Cell Biology","Computational Biology","Molecular Biology"]
doi:10.7717/peerj.4473
236 downloads
1,101 views

Considering complicated microRNA (miRNA) biogenesis and action mechanisms, it was thought so high energy-consuming for a cell to afford simultaneous over-expression of many miRNAs. Thus it prompts that an alternative miRNA regulation pattern on protein-encoding...

["Bioinformatics","Cell Biology","Computational Biology"]
doi:10.7717/peerj.3682
2 citations
360 downloads
2,430 views

Autophagy serves as a turnover mechanism for the recycling of redundant and/or damaged macromolecules present in eukaryotic cells to re-use them under starvation conditions via a double-membrane structure known as autophagosome. A set of eukaryotic genes called...

["Bioinformatics","Cell Biology","Computational Biology"]
doi:10.7717/peerj.2878
1 citation
234 downloads
1,330 views

Background Shugoshins (SGOs) are proteins that protect cohesins located at the centromeres of sister chromatids from their early cleavage during mitosis and meiosis in plants, fungi, and animals. Their function is to prevent premature sister-chromatid disjunction...

["Bioinformatics","Cell Biology","Computational Biology","Evolutionary Studies"]
doi:10.7717/peerj.2736
6 citations
379 downloads
2,658 views

There has been steady improvement in methods for capturing bioimages. However analysing these images still remains a challenge. The Python programming language provides a powerful and flexible environment for scientific computation. It has a wide range of supporting...

["Bioinformatics","Cell Biology","Computational Biology","Human-Computer Interaction","Computational Science"]
doi:10.7717/peerj.2674
1 citation
375 downloads
1,229 views

Cellular aging in Saccharomyces cerevisiae can lead to genomic instability and impaired mitotic asymmetry. To investigate the role of oxidative stress in cellular aging, we examined the effect of exogenous hydrogen peroxide on genomic instability and mitotic asymmetry...

["Cell Biology","Computational Biology","Mathematical Biology"]
doi:10.7717/peerj.2671
3 citations
367 downloads
1,651 views

MicroRNAs (miRNAs) are small endogenous noncoding RNAs that play an instrumental role in post-transcriptional modulation of gene expression. Genes related to osteogenesis (i.e., RUNX2, COL1A1 and OSX) is important in controlling the differentiation of mesenchymal...

["Cell Biology","Computational Biology","Computational Science"]
doi:10.7717/peerj.1976
7 citations
353 downloads
1,828 views

Mathematical models of collective cell movement often neglect the effects of spatial structure, such as clustering, on the population dynamics. Typically, they assume that individuals interact with one another in proportion to their average density (the mean-field...

["Cell Biology","Computational Biology","Mathematical Biology","Computational Science"]
doi:10.7717/peerj.1689
2 citations
339 downloads
2,359 views

Embryonic cell division is a mechanical process which is predominantly driven by contraction of the cleavage furrow and response of the remaining cellular matter. While most previous studies focused on contractile ring mechanisms of cytokinesis, effects of environmental...

["Biophysics","Cell Biology","Computational Biology","Developmental Biology"]
doi:10.7717/peerj.1490
410 downloads
2,195 views

Background. Human embryonic stem cells (hESCs) are pluripotent cells derived from the inner cell mass of in vitro fertilised blastocysts, which can either be maintained in an undifferentiated state or committed into lineages under determined culture conditions....

["Cell Biology","Computational Biology","Developmental Biology","Molecular Biology"]
doi:10.7717/peerj.618
4 citations
525 downloads
2,409 views

Multiple cell types form specialized protein complexes that are used by the cell to actively degrade the surrounding extracellular matrix. These structures are called podosomes or invadopodia and collectively referred to as invadosomes. Due to their potential importance...

["Bioengineering","Bioinformatics","Cell Biology","Computational Biology","Computational Science"]
doi:10.7717/peerj.462
78 citations
4,273 downloads
14,128 views

Exosomes are nanosized (30–100 nm) membrane vesicles secreted by most cell types. Exosomes have been found to contain various RNA species including miRNA, mRNA and long non-protein coding RNAs. A number of cancer cells produce elevated levels of exosomes. Because...

["Bioinformatics","Cell Biology","Computational Biology","Genetics","Oncology"]
doi:10.7717/peerj.201
38 citations
1,522 downloads
7,937 views

Genome-wide microarray technology has facilitated the systematic discovery of diagnostic biomarkers of cancers and other pathologies. However, meta-analyses of published arrays often uncover significant inconsistencies that hinder advances in clinical practice....

["Bioinformatics","Cell Biology","Computational Biology","Genomics","Dermatology"]
doi:10.7717/peerj.49

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