Moist, high-altitude grasslands of eastern South African harbour rich avian diversity and endemism. This area is also threatened by increasingly intensive agriculture and land conversion for energy production. This conflict is particularly evident at Ingula, an...

["Biodiversity","Ecology","Environmental Sciences","Statistics"]
doi:10.7717/peerj.6276
174 downloads
430 views

Translational models that utilize omics data generated in in vitro studies to predict the drug efficacy of anti-cancer compounds in patients are highly distinct, which complicates the benchmarking process for new computational approaches. In reaction to this, we...

["Computational Biology","Genomics","Statistics","Data Mining and Machine Learning"]
doi:10.7287/peerj.preprints.27256v2
781 downloads
1,248 views

We suggest twenty immediately actionable steps to reduce widespread inferential errors related to “statistical significance testing.” Our propositions refer first to the theoretical preconditions for using p-values. They furthermore include wording guidelines as...

["Science Policy","Statistics"]
doi:10.7287/peerj.preprints.3482v4
54 downloads
191 views

Background Electrochemical signals play an important role in cell communication and behavior. Electrically charged ions transported across cell membranes maintain an electrochemical imbalance that gives rise to bioelectric signaling, called membrane potential or...

["Bioengineering","Cell Biology","Statistics"]
doi:10.7717/peerj.6341
94 downloads
241 views

One reason for the widespread success of random forests (RFs) is their ability to analyze most datasets without preprocessing. For example, in contrast to many other statistical methods and machine learning approaches, no recoding such as dummy coding is required...

["Statistics","Data Mining and Machine Learning","Data Science"]
doi:10.7717/peerj.6339
129 downloads
171 views

We previously reported MetaBAT, an automated metagenome binning software tool to reconstruct single genomes from microbial communities for subsequent analyses of uncultivated microbial species. MetaBAT has become one of the most popular binning tools largely due...

["Bioinformatics","Computational Biology","Genomics","Microbiology","Statistics"]
doi:10.7287/peerj.preprints.27522v1
310 downloads
1,566 views

Biological color may be adaptive or incidental, seasonal or permanent, species- or population-specific, or modified for breeding, defense or camouflage. Although color is a hugely informative aspect of biology, quantitative color comparisons are notoriously difficult....

["Biodiversity","Evolutionary Studies","Statistics"]
doi:10.7717/peerj.6398
36 downloads
170 views

Clinical studies/trials are experiments or observations on human subjects considered by the scientific community the most appropriate instrument to answer specific research questions on interventions on health outcomes. The time-line of the observations might be...

["Bioinformatics","Clinical Trials","Epidemiology","Statistics","Data Mining and Machine Learning"]
doi:10.7717/peerj.6363
40 downloads
182 views

Objective In evidence synthesis practice, dealing with binary rare adverse events (AEs) is a challenging problem. The pooled estimates for rare AEs through traditional inverse variance (IV), Mantel-Haenszel (MH), and Yusuf-Peto (Peto) methods are suboptimal, as...

["Clinical Trials","Epidemiology","Evidence Based Medicine","Statistics"]
doi:10.7717/peerj.6295
97 downloads
894 views

Background P-curve has been proposed as a statistical test of evidential value. The distributions of sets of statistically significant p-values are tested for skewness. P-curves of true effects are right-skewed, with greater density at lower p-values than higher...

["Science Policy","Statistics"]
doi:10.7717/peerj.6318
215 downloads
1,170 views

The recent ‘replication crisis’ in psychology has focused attention on ways of increasing methodological rigor within the behavioral sciences. Part of this work has involved promoting ‘Registered Reports’, wherein journals peer review papers prior to data collection...

["Psychiatry and Psychology","Statistics"]
doi:10.7717/peerj.6232
83 downloads
295 views

Background Epidemiological surveillance of HIV infection in Japan involves two technical problems for directly applying a classical backcalculation method, i.e., (i) all AIDS cases are not counted over time and (ii) people diagnosed with HIV have received antiretroviral...

["Epidemiology","HIV","Infectious Diseases","Public Health","Statistics"]
doi:10.7717/peerj.6275
80 downloads
294 views

Background Researches on artificial livers greatly contribute to the clinical treatments for liver failure. This study aimed to evaluate the research output of artificial livers and citations from 2004 to 2017 through a bibliometric analysis. Methods A list of...

["Gastroenterology and Hepatology","Statistics","Data Science"]
doi:10.7717/peerj.6178
47 downloads
355 views

The way people behave in traffic is not always optimal from the road safety perspective: drivers exceed speed limits, misjudge speeds or distances, tailgate other road users or fail to perceive them. Such behaviors are commonly investigated using self-report-based...

["Psychiatry and Psychology","Statistics"]
doi:10.7717/peerj.6119
178 downloads
245 views

Statistical analysis of trait-environment association is challenging owing to the lack of a common observation unit: Community weighted mean regression (CWM) uses site points, multilevel models use species points, and the fourth corner correlation uses all species-site...

["Ecology","Statistics","Climate Change Biology"]
doi:10.7287/peerj.preprints.27439v1

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