35 downloads
283 views

ZBTB38 belongs to the zinc finger protein family and contains the typical BTB domains. As a transcription factor, ZBTB38 is involved in cell regulation, proliferation and apoptosis, whereas, functional deficiency of ZBTB38 induces the human neuroblastoma (NB) cell...

["Bioinformatics","Cell Biology","Genomics","Nephrology","Oncology"]
doi:10.7717/peerj.6352
41 downloads
181 views

Background Cyclin A overexpression is found in a variety of human tumors and correlates with unfavorable outcome. We analyzed immunohistochemical expression of cyclin A in Wilms tumor (WT) in relation to clinicopathological characteristics, preoperative chemotherapy...

["Nephrology","Oncology","Pathology","Pediatrics","Urology"]
doi:10.7717/peerj.6212
156 downloads
246 views

Both animal hibernation (heterothermy) and human renal osteodystrophy are characterized by high levels of serum parathyroid hormone. To test the hypothesis of hibernation in an extinct human species, we examined the hominin skeletal collection from Sima de los...

["Anthropology","Paleontology","Anatomy and Physiology","Nephrology","Metabolic Sciences"]
doi:10.7287/peerj.preprints.27370v1
194 downloads
613 views

Background Acute kidney injury (AKI) is associated with a significant increase in morbidity, mortality, and health care costs. In intensive care units (ICU), AKI is commonly multifactorial and frequently involves diverse factors, such as hypovolemia, sepsis, and...

["Nephrology","Pharmacology","Public Health"]
doi:10.7717/peerj.5405
108 downloads
494 views

Background Minimal change disease (MCD) is a form of idiopathic nephrotic syndrome. Compared to children, adult-onset MCD patients are reported to have delayed responses to glucocorticoid treatment. Several studies of children have suggested detecting urinary CD80...

["Immunology","Nephrology"]
doi:10.7717/peerj.5400
82 downloads
407 views

Background Medicare is one of the world’s largest health insurance programs. It provides health insurance to nearly 44 million beneficiaries whose entitlements are based on age, disability, or end-stage renal disease (ESRD). Data of these ESRD beneficiaries are...

["Epidemiology","Health Policy","Nephrology","Public Health","Statistics"]
doi:10.7717/peerj.5284
108 downloads
397 views

Objective To verify self-reported basic and instrumental activities of daily living (IADL) with a disability and the results of performance-based tests (namely the Taiwan performance-based IADL (TPIADL), the 2-minute step test (2MST), the 30-second chair-stand...

["Geriatrics","Global Health","Internal Medicine","Nephrology"]
doi:10.7717/peerj.5286
92 downloads
371 views

Background The importance of circulating antibodies as biomarkers of kidney disease has recently been recognized. However, no study has systematically described the methodology of sample preparation and storage regarding antibodies as biomarkers of kidney disease....

["Immunology","Internal Medicine","Nephrology"]
doi:10.7717/peerj.5178
140 downloads
681 views

Background The vermiform appendix serves as a “safe house” for maintaining normal gut bacteria and appendectomy may impair the intestinal microbiota. Appendectomy is expected to profoundly alter the immune system and modulate the pathogenic inflammatory immune...

["Microbiology","Diabetes and Endocrinology","Internal Medicine","Nephrology"]
doi:10.7717/peerj.5019
112 downloads
580 views

Introduction Ureteropelvic junction obstruction (UPJO) is a common congenital anomaly leading to varying degrees of hydronephrosis (HN), ranging from no apparent effect on the renal function to atrophy. Evaluation of these children is based on Diuretic Renal Scintigraphy...

["Nephrology","Pediatrics","Radiology and Medical Imaging","Urology"]
doi:10.7717/peerj.4791
209 downloads
796 views

Background Chronic kidney disease (CKD) is characterised by long-term kidney damage and renal function decline. Diabetic CKD is the principal subtype of kidney disease in Malaysia and is associated with oxidative stress which plays an important role in development...

["Diabetes and Endocrinology","Nephrology"]
doi:10.7717/peerj.4421
160 downloads
630 views

Background Renal biopsies performed in diabetic patients are increasing and becoming more complex. Comprehensive data on modern spectrum of biopsy-proven renal disease in Chinese diabetic patients are lacking. Methods In a nationwide renal biopsy survey including...

["Diabetes and Endocrinology","Epidemiology","Nephrology","Pathology"]
doi:10.7717/peerj.4522
2 citations
149 downloads
728 views

Background Minimal change disease (MCD) is a kind of nephrotic syndrome (NS). In this study, we aimed to establish a mathematical diagnostic model based on biological parameters to classify MCD. Methods A total of 798 NS patients were divided into MCD group and...

["Bioinformatics","Epidemiology","Nephrology"]
doi:10.7717/peerj.4237
199 downloads
666 views

Background Osteoprotegerin (OPG) is a potential biomarker for severity and complications of cardiovascular diseases. Peripheral arterial disease (PAD) is associated with an increased risk of death in kidney transplantation (KT) patients. This prospective cross-sectional...

["Nephrology","Surgery and Surgical Specialties"]
doi:10.7717/peerj.3847
2 citations
120 downloads
828 views

Background Frailty exhibits a high prevalence in end-stage renal disease (ESRD) patients and is associated with adverse health-related outcomes, including falls and fractures. Available studies do not address whether frailty is associated with temporal changes...

["Geriatrics","Nephrology","Palliative Care"]
doi:10.7717/peerj.3542

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