18 downloads
70 views

Background: Medical decision-making is difficult when information is limited due to rareness. For example, there are two treatment options for patients affected by a rare disease with high lethality. The information about both treatment effects is unavailable or...

["Bioinformatics","Clinical Trials","Public Health","Ethical Issues","Statistics"]
doi:10.7287/peerj.preprints.27170v1
196 downloads
579 views

Using the term "Open data" has become a bit of a fashion, but using it without clear specifications is misleading i.e. it can be considered just an empty phrase. Probably even worse is the term "Open Science" — can science be NOT open at all? Are we reinventing...

["Ethical Issues","Legal Issues","Science Policy","Spatial and Geographic Information Science"]
doi:10.7287/peerj.preprints.27127v1
121 downloads
425 views

The success of personalized medicine does not only rely on methodological advances but also on the availability of data to learn from. While the generation and sharing of large data sets is becoming increasingly easier, there is a remarkable lack of diversity within...

["Genomics","Neuroscience","Ethical Issues","Data Mining and Machine Learning","Data Science"]
doi:10.7287/peerj.preprints.27079v1
81 downloads
456 views

Background Angiotensin-converting enzyme inhibitors (ACEi) and angiotensin receptor blockers (ARB) are the most commonly prescribed antihypertensive medications in higher-risk surgical patients. However, there is no clinical consensus on their use in the perioperative...

["Anesthesiology and Pain Management","Surgery and Surgical Specialties","Ethical Issues"]
doi:10.7717/peerj.5061
1,287 downloads
3,276 views

This article proposes quantitative answers to meta-scientific questions including "how much knowledge is attained by a research field?","how rapidly is a field making progress?", "what is the expected reproducibility of a result?", "how much knowledge is lost from...

["Computational Biology","Ethical Issues","Science Policy","Statistics","Computational Science"]
doi:10.7287/peerj.preprints.1968v4
452 downloads
1,000 views

Research products that lack transparency and are influenced by confirmation bias lead to barriers that, when left unchecked, propagate throughout the scientific record and lead to wasted research effort. Phylogenetics is particularly vulnerable given its ever-evolving...

["Evolutionary Studies","Ethical Issues"]
doi:10.7287/peerj.preprints.26585v3
481 downloads
782 views

Authorship of publications is the main way scientists received credit for their academic research. But as scientific research projects have become larger and more collaborative, the number of contributors has increased, and so has the potential for disputes over...

["Ethical Issues","Legal Issues","Science Policy"]
doi:10.7287/peerj.preprints.26987v1
3,089 downloads
6,334 views

Scientific publications have not traditionally been accompanied by data, either during the peer review process or when published. Concern has arisen that the literature in many fields may contain inaccuracies or errors that cannot be detected without inspecting...

["Ethical Issues","Science and Medical Education","Statistics"]
doi:10.7287/peerj.preprints.26968v1
498 downloads
1,466 views

The institutions of science are in a state of flux. Declining public funding for basic science, the increasingly corporatized administration of universities, increasing “adjunctification” of the professoriate and poor academic career prospects for postdoctoral...

["Ethical Issues","Science and Medical Education","Science Policy"]
doi:10.7287/peerj.preprints.26885v2
2 citations
182 downloads
1,878 views

The use of small unoccupied aircraft systems (UAS) for ecological studies and wildlife population assessments is increasing. These methods can provide significant benefits in terms of costs and reductions in human risk, but little is known if UAS-based approaches...

["Conservation Biology","Ecology","Environmental Sciences","Marine Biology","Ethical Issues"]
doi:10.7717/peerj.4467
134 downloads
466 views

We describe the scientific community of an India effort, the Bioinfomatics Club for Experimenting Scientists (Bioclues) whose aim works on four avenues, viz. Mentoring, Outreach, Research and Entrepreneurship (MORE). Incepted in the year 2005, the organization...

["Bioinformatics","Biotechnology","Ethical Issues","Science and Medical Education","Science Policy"]
doi:10.7287/peerj.preprints.26503v1
1,094 downloads
4,220 views

Fallibility in science cuts both ways: it poses dilemmas for the scientist who discovers errors in their own work, and for those who discover errors in the work of others. The ethical response to finding errors in one's own work is clear: they should be claimed...

["Psychiatry and Psychology","Ethical Issues","Science Policy"]
doi:10.7287/peerj.preprints.3486v1
3 citations
635 downloads
5,677 views

Despite significant progress, there is still a gender gap in science all over the world, especially at senior levels. Some progressive countries are recognizing the need to address barriers to gender equality in order to retain their best scientists and innovators,...

["Ethical Issues","Science Policy"]
doi:10.7717/peerj.4000
217 downloads
2,351 views

Background Publication bias is a form of scientific misconduct. It threatens the validity of research results and the credibility of science. Although several tests on publication bias exist, no in-depth evaluations are available that examine which test performs...

["Ethical Issues","Science Policy","Statistics"]
doi:10.7717/peerj.4115
3,200 downloads
665 views

Underpowered experiments have three problems: the probability of a false positive result is higher, true effects are harder to detect, and the true effects that are detected tend to have inflated effect sizes. Many biology experiments are underpowered and recent...

["Animal Behavior","Neuroscience","Drugs and Devices","Ethical Issues","Statistics"]
doi:10.7287/peerj.preprints.3363v1

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