45 downloads
124 views

Background The management of diabetic foot complications is challenging, time-consuming and costly. Such complications frequently recur, and the feet of individuals with diabetes can be easily infected. The variables that predict foot care behaviours must be identified...

["Diabetes and Endocrinology","Nursing"]
doi:10.7717/peerj.6416
73 downloads
130 views

Backgrounds Environmental factors during early life alter the hypothalamus-pituitary-adrenal (HPA) axis regulation and increase the risk of diseases in later life. However, adrenal function at each developmental stage has not fully been investigated in relation...

["Diabetes and Endocrinology","Pediatrics"]
doi:10.7717/peerj.6368
40 downloads
249 views

In general, type 2 diabetes (T2D) usually occurs in middle-aged and elderly people. However, the incidence of childhood-onset T2D has increased all across the globe. Therefore, it is very important to determine the molecular and genetic mechanisms of childhood-onset...

["Bioinformatics","Diabetes and Endocrinology"]
doi:10.7717/peerj.6343
31 downloads
75 views

Follicle-stimulating hormone (FSH), which is synthesized and secreted by the anterior pituitary gland, plays an important role in regulating reproductive processes. In this study, using the TargetScan program, we predicted that miRNAs regulate FSH secretion. Dual-luciferase...

["Cell Biology","Molecular Biology","Diabetes and Endocrinology"]
doi:10.7287/peerj.preprints.27503v1
67 downloads
234 views

Objectives Mechanical loading may be an important factor in the regulation of bone derived hormones involved in phosphate homeostasis. This study investigated the effects of peak power and endurance training on expression levels of fibroblast growth factor 23 (FGF23)...

["Anatomy and Physiology","Diabetes and Endocrinology","Internal Medicine","Kinesiology"]
doi:10.7717/peerj.6184
85 downloads
274 views

Background Diabetic kidney disease is the most common cause of chronic kidney disease (CKD). An early event in diabetic kidney disease is alteration of the glomerular basement membrane and the mesangial expansion. Matrix metalloproteinases (MMP) are a family of...

["Biochemistry","Diabetes and Endocrinology","Urology"]
doi:10.7717/peerj.6067
48 downloads
131 views

Neurological diseases (NDs) are progressive disorder often advances with age and comorbidities of Type 2 diabetes (T2D). Epidemiological, clinical and neuropathological evidence advocate that patients with T2D are at an increased risk of getting NDs. However, it...

["Bioinformatics","Computational Biology","Genetics","Genomics","Diabetes and Endocrinology"]
doi:10.7287/peerj.preprints.27323v1
114 downloads
437 views

Aim Anaplastic thyroid carcinoma (ATC) is the most lethal thyroid malignancy. Identification of novel drug targets is urgently needed. Materials & Methods We re-analyzed several GEO datasets by systematic retrieval and data merging. Differentially expressed genes...

["Genetics","Diabetes and Endocrinology","Oncology"]
doi:10.7717/peerj.5822
1 citation
73 downloads
513 views

Chemerin is an adipocyte derived signalling molecule (adipokine) that serves as a ligand activator of Chemokine-like receptor 1(CMKLR1). Chemerin/CMKLR1 signalling is well established to regulate fundamental processes in metabolism and inflammation. The composition...

["Bioinformatics","Genomics","Diabetes and Endocrinology","Metabolic Sciences"]
doi:10.7717/peerj.5494
179 downloads
747 views

Sarcopenia is an age-related disease characterized by the loss of muscle mass and muscle function. A proper understanding of its pathogenesis and mechanisms may lead to new strategies for diagnosis and treatment of the disease. This study aims to discover the underlying...

["Bioinformatics","Diabetes and Endocrinology","Geriatrics","Medical Genetics"]
doi:10.7717/peerj.5239
63 downloads
138 views

Tropomodulins (Tmods) are proteins that cap the slow growing (pointed) ends of actin filaments (F-actin). The basis for our current understanding of Tmod function comes from studies in cells with relatively stable and highly organized F-actin networks, leading...

["Biochemistry","Cell Biology","Molecular Biology","Anatomy and Physiology","Diabetes and Endocrinology"]
doi:10.7287/peerj.preprints.27172v1
2 citations
114 downloads
490 views

Background Adult rat epididymal adipocytes are able to convert large amounts of glucose to lactate and glycerol. However, fatty acid efflux is much lower than that expected from glycerol levels if they were the product of lipolysis. Use of glucose for lipogenesis...

["Biochemistry","Diabetes and Endocrinology","Metabolic Sciences"]
doi:10.7717/peerj.5440
133 downloads
573 views

Background Differently expressed circular RNAs (circRNAs) have been reported to play a considerable role in tumor behavior; however, the expression profile and biological function of circRNAs in papillary thyroid carcinoma (PTC) remains unknown. Thus, the study...

["Genetics","Diabetes and Endocrinology","Oncology"]
doi:10.7717/peerj.5363
55 downloads
168 views

Characterized by high blood glucose concentration, resistance of cells to glucose uptake and reduced insulin sensitivity, Type II diabetes is a major health problem afflicting both developing and developed countries in increasing extent as populations around the...

["Biochemistry","Cell Biology","Diabetes and Endocrinology","Internal Medicine","Metabolic Sciences"]
doi:10.7287/peerj.preprints.27024v1
3 citations
258 downloads
892 views

Background Obesity-induced glucose metabolism disorder is associated with chronic, low-grade, systemic inflammation and is considered a risk factor for diabetes and metabolic syndrome. Resveratrol (RES), a natural anti-inflammatory compound, is observed to improve...

["Diabetes and Endocrinology","Immunology","Nutrition","Metabolic Sciences"]
doi:10.7717/peerj.5173

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