20 downloads
124 views

Tris(1,3-dichloro-2-propyl) phosphate (TDCIPP) is a high-production volume organophosphate flame retardant widely used within the United States. Within zebrafish, initiation of TDCIPP exposure at 0.75 h post-fertilization (hpf) results in genome-wide alterations...

["Developmental Biology","Toxicology","Ecotoxicology"]
doi:10.7717/peerj.4156
11 downloads
62 views

Purpose: This study was performed to investigate the expression pattern of Wnt inhibitory factor 1 (Wif1) during anorectal development in normal and anorectal malformation (ARM) embryos and the possible role of Wif1 in the pathogenesis of ARM. Methods: ARM was...

["Developmental Biology","Gastroenterology and Hepatology","Pediatrics"]
doi:10.7287/peerj.preprints.3459v1
41 downloads
214 views

The mechanistic target of rapamycin (mTOR) and ryanodine receptor (RyR) signaling pathways regulate fundamental processes of neurodevelopment, and genetic mutations within these pathways have been linked to neurodevelopmental disorders. While previous studies have...

["Developmental Biology","Neuroscience","Toxicology"]
doi:10.7717/peerj.4106
54 downloads
1,985 views

Previous studies have used the zebrafish to investigate the biology of lens crystallin proteins and their roles in development and disease. However, little is known about zebrafish α-crystallin promoter function, how it compares to that of mammals, or whether mammalian...

["Developmental Biology","Molecular Biology","Neuroscience","Ophthalmology"]
doi:10.7717/peerj.4093
51 downloads
505 views

Although in recent years the study of gene expression variation in the absence of genetic or environmental cues or gene expression heterogeneity has intensified considerably, many basic and applied biological fields still remain unaware of how useful the study...

["Developmental Biology","Genomics"]
doi:10.7717/peerj.4004
109 downloads
925 views

The study of vertebrate ontogenies has the potential to inform us of shared developmental patterns and processes among organisms. However, fossilised ontogenies of early vertebrates are extremely rare during the Palaeozoic Era. A growth series of the Late Devonian...

["Developmental Biology","Evolutionary Studies","Paleontology"]
doi:10.7717/peerj.3969
65 downloads
121 views

The discovery of induced pluripotent stem cells (iPSCs) by Shinya Yamanaka in 2006 was heralded as a major breakthrough of the decade in stem cell research. The ability to reprogrammed human somatic cells to a pluripotent embryonic stem cell-like state through...

["Cell Biology","Developmental Biology","Genetics"]
doi:10.7287/peerj.preprints.3374v1
26 downloads
177 views

Although comparative studies of anuran ontogeny have provided new data on heterochrony in the life cycles of frogs, most of them have not included Colombian species. Using different staining techniques, we describe the cranial and poscranial elements development...

["Biodiversity","Developmental Biology","Evolutionary Studies","Taxonomy","Zoology"]
doi:10.7287/peerj.preprints.3368v1
59 downloads
172 views

Many plant species exhibit heterophylly, displaying different leaves upon a single plant. The molecular mechanisms regulating this phenomenon, however, have remained elusive. In this study, the transcriptomes of submerged and floating leaves of an aquatic heterophyllous...

["Cell Biology","Developmental Biology","Evolutionary Studies","Genetics","Plant Science"]
doi:10.7287/peerj.preprints.3336v1
81 downloads
384 views

Background Although spermatozoa with normal morphology are assumed to have uniform fertilization ability, recent data show that even normal spermatozoa have considerable variation in their head shape which is associated with differences in fertilization ability....

["Cell Biology","Developmental Biology","Andrology"]
doi:10.7717/peerj.3913
80 downloads
412 views

Predation is the main cause of mortality during early life stages. The ability to avoid and evade potential threats is, therefore, favoured to evolve during the early stages of life. It is also during these early stages that the process of familiarization occurs....

["Animal Behavior","Aquaculture, Fisheries and Fish Science","Developmental Biology"]
doi:10.7717/peerj.3899
66 downloads
772 views

If fertilization of matured oocyte does not occur, unfertilized oocyte undergoes aging, resulting in a time-dependent reduction of the oocyte’s quality. The aging of porcine oocytes can lead to apoptosis. Carbon monoxide (CO), a signal molecule produced by the...

["Biotechnology","Cell Biology","Developmental Biology","Veterinary Medicine"]
doi:10.7717/peerj.3876
84 downloads
364 views

Objective The present study aimed to assess the effects of exercise with dietary restriction on cardiac autonomic activity, arterial stiffness, and cardiovascular biomarkers in obese individuals. Methods Seventeen obese adults completed an 8-week exercise and dietary...

["Developmental Biology","Neuroscience","Cardiology","Clinical Trials"]
doi:10.7717/peerj.3900
99 downloads
354 views

Phenotypic differences between closely related taxa or populations can arise through genetic variation or be environmentally induced, in both cases leading to altered transcription of genes during the structural and functional development of the body. Comparative...

["Developmental Biology","Ecology","Evolutionary Studies","Genomics","Freshwater Biology"]
doi:10.7287/peerj.preprints.3318v1
29 downloads
179 views

Quality disciplines have been widely used for decades in industrial and business fields. It is only in recent times, however, that Quality management and approaches have received proper attention in life science. The development, optimization, validation and dissemination...

["Biochemistry","Cell Biology","Developmental Biology","Ethical Issues","Science Policy"]
doi:10.7287/peerj.preprints.3316v1

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