293 downloads
845 views

Background We have previously reported anticancer activities of Melicope ptelefolia (MP) leaf extracts on four different cancer cell lines. However, the underlying mechanisms of actions have yet to be deciphered. In the present study, the anticancer activity of...

["Biochemistry","Biotechnology","Oncology"]
doi:10.7717/peerj.5203
1 citation
151 downloads
679 views

Army ants are keystone species in many tropical ecosystems. Yet, little is known about the chemical compounds involved in army ant communication. In the present study, we analyzed the volatile mandibular gland secretions—triggers of ant alarm responses—of six Neotropical...

["Biochemistry","Evolutionary Studies","Zoology"]
doi:10.7717/peerj.5319
154 downloads
571 views

Pleurotus tuoliensis, a kind of valuable and favorable edible mushroom in China, is always subjected to high environmental temperature during cultivation. In our previous study with P. tuoliensis, trehalose proved to be effective for tolerating heat stress. Trehalose-6-phosphate...

["Agricultural Science","Biochemistry","Biotechnology","Microbiology","Molecular Biology"]
doi:10.7717/peerj.5230
59 downloads
176 views

Characterized by high blood glucose concentration, resistance of cells to glucose uptake and reduced insulin sensitivity, Type II diabetes is a major health problem afflicting both developing and developed countries in increasing extent as populations around the...

["Biochemistry","Cell Biology","Diabetes and Endocrinology","Internal Medicine","Metabolic Sciences"]
doi:10.7287/peerj.preprints.27024v1
163 downloads
856 views

Acinus is an abundant nuclear protein involved in apoptosis and splicing. It has been implicated in inducing apoptotic chromatin condensation and DNA fragmentation during programmed cell death. Acinus undergoes activation by proteolytic cleavage that produces a...

["Biochemistry","Molecular Biology"]
doi:10.7717/peerj.5163
224 downloads
1,199 views

Many proteins display complex dynamical properties that are often intimately linked to their biological functions. As the native state of a protein is best described as an ensemble of conformations, it is important to be able to generate models of native state...

["Biochemistry","Computational Biology"]
doi:10.7717/peerj.5125
157 downloads
820 views

Insects provide an accessible system to study the contribution of DNA methylation to complex epigenetic phenotypes created to regulate gene expression, chromatin states, imprinting and dosage compensation. The members of genus Drosophila have been used as a model...

["Biochemistry","Molecular Biology","Zoology"]
doi:10.7717/peerj.5119
123 downloads
143 views

Large culture volume in bioreactor necessitates aeration for providing sufficient oxygen for cell growth. Thus, extend of aeration and amount of anti-foam needed for suppressing foam formation are key parameters determining the success of bioreactor fermentation....

["Biochemistry","Bioengineering","Biotechnology","Cell Biology","Microbiology"]
doi:10.7287/peerj.preprints.27014v1
1 citation
147 downloads
719 views

The aim of this study was to determine the role of the perlecan (Hspg2) heparan sulphate (HS) side chains on cell and matrix homeostasis in tail and Achilles tendons in 3 and 12 week old Hspg2 exon 3 null HS deficient (Hspg2Δ3 − ∕Δ3 −) and C57 BL/6 Wild Type (WT)...

["Biochemistry","Anatomy and Physiology"]
doi:10.7717/peerj.5120
113 downloads
291 views

GDF11, a member of TGF-β superfamily, has recently received widespread attention as a novel anti-ageing/rejuvenation factor to reverse age-related dysfunctions in heart and skeletal muscle, and to induce angiogenesis and neurogenesis. However, these positive effects...

["Biochemistry","Bioinformatics","Cell Biology","Neuroscience","Evidence Based Medicine"]
doi:10.7287/peerj.preprints.27003v1
226 downloads
857 views

The present study first identified the biotransformation of starch as a novel preparation method was investigated using the alpha-transglucosidase-producing Geobacillus stearothermophilus U2. Subsequently, 5 L- and 20 L-scale fermentations were performed. After...

["Biochemistry","Biotechnology","Microbiology"]
doi:10.7717/peerj.5086
152 downloads
313 views

The processes of association and dissociation of ribosomal subunits are of great importance for the protein biosynthesis. The mechanistic details of these processes, however, are not well known. In bacteria, upon translation termination, ribosome dissociates into...

["Biochemistry","Molecular Biology"]
doi:10.7287/peerj.preprints.26997v1
366 downloads
839 views

The phosphoinositide 3-kinase (PI3K) pathway shows frequent aberrant alterations and pathological activation in breast cancer cells. While PI3K inhibitors have not achieved expectant therapeutic efficacy in clinical trials, and several studies provide promising...

["Biochemistry","Oncology"]
doi:10.7717/peerj.5092
107 downloads
617 views

Background Entolimod is a Salmonella enterica flagellin derivate. Previous work has demonstrated that entolimod effectively protects mice and non-human primates from ionizing radiation. However, it caused a “flu-like” syndrome after radioprotective and anticancer...

["Biochemistry","Bioengineering","Biotechnology"]
doi:10.7717/peerj.5043
116 downloads
562 views

The archaellum, the rotating motility structure of archaea, is best studied in the crenarchaeon Sulfolobus acidocaldarius. To better understand how assembly and rotation of this structure is driven, two ATP-binding proteins, FlaI and FlaH of the motor complex of...

["Biochemistry","Microbiology","Molecular Biology"]
doi:10.7717/peerj.4984

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