104 downloads
381 views

Background Diabetic kidney disease is the most common cause of chronic kidney disease (CKD). An early event in diabetic kidney disease is alteration of the glomerular basement membrane and the mesangial expansion. Matrix metalloproteinases (MMP) are a family of...

["Biochemistry","Diabetes and Endocrinology","Urology"]
doi:10.7717/peerj.6067
101 downloads
424 views

Background DNA repair is essential to counteract damage to DNA induced by endo- and exogenous factors, to maintain genome stability. However, challenges to the faithful discrimination between damaged and non-damaged DNA strands do exist, such as mismatched pairs...

["Biochemistry","Cell Biology","Genetics","Molecular Biology","Oncology"]
doi:10.7717/peerj.6029
87 downloads
428 views

Aedes albopictus is a primary vector of hundreds of pathogens. Strong environmental adaptability and extensive global distribution of Aedes albopictus make it a severe threat to human health. Autophagy is a cellular process involved in maintenance of cellular homeostasis...

["Biochemistry","Cell Biology","Entomology","Molecular Biology","Parasitology"]
doi:10.7717/peerj.5988
52 downloads
116 views

The exploring of biological processes in vitro under conditions of macromolecular crowding is a way to achieve an understanding of how these processes occur in vivo. In this work, we study the unfolding of the fluorescent probe iRFP713 in crowded environment in...

["Biochemistry","Biophysics","Molecular Biology"]
doi:10.7287/peerj.preprints.27368v1
88 downloads
409 views

T1 Lipase is a thermostable secretary protein of Geobacillus zalihae strain previously expressed in a prokaryotic system and purified using three-step purification: affinity 1, affinity 2, and ion exchange chromatography (IEX). This approach is time consuming and...

["Biochemistry","Computational Biology"]
doi:10.7717/peerj.5833
84 downloads
506 views

Objective A putative relationship between markers for the serotonin system and the personality scale self-transcendence (ST) and its subscale spiritual acceptance (SA) has been demonstrated in a previous PET study of 5-HT1A receptor binding in healthy control subjects....

["Biochemistry","Neuroscience","Psychiatry and Psychology","Statistics"]
doi:10.7717/peerj.5790
85 downloads
149 views

Background. Methylmalonic acidemia is a rare inborn error of metabolism caused by mutations in methylmalonyl−CoA mutase (MUT) gene. As intermediate of propionate metabolism, MUT converts methylmalonyl−CoA into succinyl−CoA, which enters the Krebs cycle. Downstream...

["Biochemistry","Bioinformatics","Biotechnology","Metabolic Sciences"]
doi:10.7287/peerj.preprints.27335v1
42 downloads
129 views

Several programs have been developed that are able to replace a residue with another one in a protein structure, but usually they are not able to simulate the short- and long-range effects of a real single point mutation. We tested if the approach of re-modelling...

["Biochemistry","Bioinformatics","Computational Biology"]
doi:10.7287/peerj.preprints.27326v1
49 downloads
105 views

The prediction of the stability of a protein is a very important issue in computational biology. Indeed, missense mutations are frequently associated to a change in protein stability, leading usually to destabilization, unfolding and aggregation. However, the direct...

["Biochemistry","Bioinformatics","Computational Biology"]
doi:10.7287/peerj.preprints.27319v1
102 downloads
419 views

Long-term use of organophosphorus (OP) compounds has become an increasing global problem and a major threat to sustainability and human health. Prolidase is a proline-specific metallopeptidase that can offer an efficient option for the degradation of OP compounds....

["Biochemistry","Biotechnology","Microbiology"]
doi:10.7717/peerj.5863
3 citations
361 downloads
3,713 views

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), two late onset neurodegenerative diseases, have been shown to share overlapping cellular pathologies and genetic origins. Studies suggest that a hexanucleotide repeat expansion in the first...

["Biochemistry","Biophysics","Molecular Biology"]
doi:10.7717/peerj.5815
120 downloads
541 views

Background Senescence-related impairment of proliferation and differentiation limits the use of dental pulp cells for tissue regeneration. Deletion of sclerostin improves the dentinogenesis regeneration, while its role in dental pulp senescence is unclear. We investigated...

["Biochemistry","Cell Biology","Molecular Biology"]
doi:10.7717/peerj.5808
1 citation
155 downloads
557 views

Leaves from three varieties of Ficus deltoidea, colloquially termed small- (FDS), medium- (FDM), and big-type leaf (FDB), were subjected to water extraction. The crude extracts were fractionated using water (WF) and ethyl acetate (EAF). The phenolic and flavonoid...

["Biochemistry","Cell Biology","Food Science and Technology","Plant Science","Translational Medicine"]
doi:10.7717/peerj.5694
88 downloads
364 views

Background In the wild, matrinchã (Brycon amazonicus) and tambaqui (Colossoma macropomum) rely strongly on their swimming capacity to perform feeding, migration and reproductive activities. Sustained swimming speed in fishes is performed almost exclusively by aerobic...

["Aquaculture, Fisheries and Fish Science","Biochemistry","Freshwater Biology"]
doi:10.7717/peerj.5719
387 downloads
655 views

The actin cytoskeleton comprises a set of filament networks that perform essential functions in eukaryotic cells. The idea that actin filaments incorporate monomers directly from solution forms both the “textbook picture” of filament elongation and a conventional...

["Biochemistry","Biophysics","Cell Biology"]
doi:10.7287/peerj.preprints.27254v1

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