Whitehead Institute for Biomedical Research
I study two potential genetic conflicts, Imprinting and Host-Transposon interactions, in A. thaliana. Imprinting is a phenomenon observed in the endosperm layer of seeds wherein the copy of the gene inherited from either the mother or the father, but not both, is predominantly expressed. Imprinting has been postulated to affect seed size and thus can directly affect agricultural output. I use genomics, microscopy and plant growth tests to understand how genes are imprinted and what roles these imprinted genes play in seed development. In an effort to understand host-transposon interactions, I am studying proteins encoded by transposons.
Tata Institute of Fundamental Research , Mumbai
July 2004 - July 2007
I studied mammalian forebrain development at the Tole Lab. During this time, I established protocols for ES cell culture and the production of chimeric mice. Carried out in collaboration with two other postdocs, my work showed that a Lim homeo-domain gene Lhx2 was a key determinant of cortical fate and was required for the formation of the hippocampus
August 2007 - February 2014
Molecular Biology and Genetics
I studied the gene Lhr which encodes a heterochromatin protein that acts as a barrier and prevents the formation of interspecies hybrids between two species of fruit flies. I found that Lhr regulates the activity of repetitive DNA in the ovaries of the fruit fly Drosophila melanogaster.