My research as a molecular biologists focused on questions regarding gene silencing mechanisms that eukaryotic cells can deploy in order to contend with foreign genetic invasions, such as transposable elements or foreign genes acquired by horizontal gene transfer (HGT). As a basic approach, it is important to know how these elements incorporate, evolve, and interact with the host genome, becoming a part of it. We also seek to understand the machinery used by the host to identify and suppress those visitors whose activity can be considered lethal in terms of cell viability. In the role of epigenetic gene silencing, where RNA research is becoming a substantial subject in gene expression regulation, non-coding RNAs (miRNAs, siRNAs, piRNAs, lncRNAs) are key parts of the process. Advances in sequencing technology and transcriptome analysis give us the opportunity to study the biological functions of RNAs in gene differentiation and develop techniques to study gene silencing mechanisms.