[Experimental] List of manuscripts available for review volunteers
1 manuscript available for review volunteers
September 26, 2017

Background: Dichromacy, an X-linked recessive disorder is identified worldwide, more in males than females. In European Caucasians, its incidence is 8% in males and 0.5% in females. In India, it is 8.73% in males and 1.69% in females, and in Iran, it is 8.18% in males and 0.43% in females. Population based epidemiological data about dichromacy in different ethnic groups of Pakistan is not available. The aim of this study was to find out population prevalence of inherited red-green dichromacy in heterogenous population of the district of Chiniot, Punjab, Pakistan, and to determine the impact of consanguinity and ethnicity

Methods: In this cross-sectional study, boys and girls of the higher secondary schools were examined in the three tehsils (administrative subdivisions) of district Chiniot. Pseudoisochromatic Ishihara Test has been employed for detection of dichromacy in the study population. The sample size was calculated statistically as 260, which was expanded to 705 and divided by population density of the three tehsils.

Results: Screening of 359 males and 346 females revealed 19 (5.29%) dichromat males and only 2 (0.58%) females. The study population belonged to 23 castes / isonym groups. The consanguinity found in the district of Chiniot is 84.82% and in the dichromat families, it is 85.71%, of which 52.37% are first cousin.

Conclusion/Suggestion: The study has shown that the incidence of dichromacy could be reduced through genetic counselling.


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