[Experimental] List of manuscripts available for review volunteers
1 manuscript available for review volunteers
December 23, 2017
Background. Intracerebral hemorrhage (ICH) in rats with acute alcohol intoxication (AAI) induces greater brain injury and neurological impairment than those without AAI. It is not clear whether chronic alcohol consumption (CAC) may cause similar outcomes in ICH rats. Methods. Sixteen Sprague-Dawley male rats were divided into two groups: CAC group (n = 8) fed with 10% alcohol in drinking water for 4 weeks, and Control group (n = 8) fed with water only. ICH was induced by collagenase infusion into the striata. Coronal T1-weighted imaging, T2-weighted imaging, T2*-weighted imaging, and diffusion-weighted imaging were generated with a 3.0T magnetic resonance imaging (MRI) scanner to investigate the changes of hemorrhagic volume and edema throughout the injury and recovery stages of ICH. Results. The hematoma volume was larger in the CAC group than in the control group (P < 0.001). These findings, however, cannot explain the findings that at post-ICH, progressive edema formation and neurological impairment were not significantly different between two groups. T2-weighted imaging is ideal for monitoring the hematoma volume in rats. Discussion. CAC induces larger hematoma volume in rats with ICH, but brain edema and neurological impairment are not correlated to CAC. The findings may suggest the ICH-induced neurological impairments relate more to the brain edema formation than hematoma enlargement.


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