[Experimental] List of manuscripts available for review volunteers
2 manuscripts available for review volunteers
November 30, 2017
Occlusive artery disease (CAD) is the leading cause of death worldwide. Bypass graft surgery remains the prevalently performed treatments for occlusive arterial disease, and veins are the most frequently used conduits for surgical revascularization. However, clinical efficacy is highly affected by the long-term potency rates of vein grafts, and there are no optimal treatments available for the prevention of vein graft restenosis (VGR) until today. Hence, there is an urgent need to improve our understanding of the molecular mechanisms involved in mediating VGR. The past decade has seen the rapid development of genomic technologies, such as the genomic sequencing and microarray technologies, which will definitely provide novel insights into potential molecular mechanisms involved in VGR program. Ironically, high-through put data associated with VGR is extremely scarce until today. The main goal of the current study was to explore potential crucial genes and pathways associated with VGR and provide valid biological information for further investigation of VGR. Based on high-throughput gene expression data, a further comprehensive bioinformatics analysis was performed. The differentially expressed genes (DEGs) were identified using R and Bioconductor packages. After functional enrichment analyses of DEGs, protein–protein interaction (PPI) network and sub-PPI network analyses were performed. Finally, 9 potential hub genes and 14 pathways were found out. In conclusion, these results not only may explain the causes of VGR, but could also open new avenues for therapeutic strategies of VGR. Despite its exploratory nature, this work offers valuable insights into our knowledge of the molecular mechanism involved in VGR.
November 1, 2017

Background: Kawasaki disease (KD) is an immune-mediated systemic vasculitis and infection plays an important role in the pathophysiology of KD. The susceptibility to infectious disease in patients with KD remains largely unclear. This study aimed to investigate the risk of respiratory tract infection (RTI)-related hospitalizations in children with KD.

Methods: Data from Taiwanese National Health Insurance Research Database was analyzed. Children with KD were selected as KD group and age- and sex-matched non-KD patients were selected as control group with 1:1 ratio. Both cohorts were tracked for 1 year to investigate the incidences of RTI-related hospitalizations. Cox regression hazard model was used to adjust for confounding factors and calculate the adjusted hazard ratio (aHR).

Results: Between January 1996 and December 2012, 13,760 patients with KD were identified as KD group and 13,709 patients were enrolled as control group. An obviously reduced risk of RTI-related hospitalizations was observed in KD patients (aHR: 0.53, 95% confidence interval: 0.49-0.57). The decreased risk persisted through the 1-year follow-up period with a peak protection in 3-6 months (aHR: 0.46, 95% confidence interval: 0.40-0.53).

Conclusions: KD patients had approximately half reduction of risk for RTI-related hospitalizations. The protective effects persisted for at least 1 year. Further studies are warranted to elucidate the entire mechanism and investigate the influences of intravenous immunoglobulin.


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