[Experimental] List of manuscripts available for review volunteers
3 manuscripts available for review volunteers
November 25, 2017

ABSTRACT

Porcine circovirus 2 (PCV2) has been prevalent in swine herds in China since 2002, causing severe economic loss to the pig industry. The number of live pigs in southeast China is > 20 million. Since information on the genetic variation of PCV2 in the Fujian province is limited, the objective of the present work was to investigate the epidemiological and evolutionary characteristics of PCV2 in southeast China from 2013 to 2017. Of the 685 samples collected from 90 different swine herds from 2013 to 2017, 356 samples from 84 different swine herds were positive for PCV2. PCV2a, PCV2b, PCV2d, and PCV2e co-existed in the Fujian province, with PCV2d-2 being the predominant circulating strain in swineherds and PCV2e being reported for the first time in China. Strikingly, PCV2-FJ-water DNA comes from contaminated river water and not infected animals. Sequence comparison among all isolates indicated that 92 isolates shared approximately 78.7–100% nucleotide identity and 74.5–100% amino acid identity for open reading frame (ORF). Amino acid alignment showed that the Cap protein of PCV2e and two strains (CN-FJ-CTS04 and FJ-6S-2017) differed markedly from those of PCV2a, PCV2b, PCV2c, and PCV2d. These results indicated that various PCV2 genotypes exist in China, and that PCV2 is continuously evolving, leading to rapid emergence of new variant stains.

November 9, 2017
Anogenital warts are caused by human papillomavirus (HPV). HPV genotype 6 and 11 are most often associated with anogenital warts. The diversity of HPV genotypes found in Thai patients with genital warts is not well-characterized. The objective of this study was to investigate HPV-associated anogenital warts in the Thai population and whether genotypes found are represented in the vaccine. A total of 206 anogenital swab samples were analyzed for HPV DNA by PCR and sequencing. HPV positive was identified in 88.3% (182/206) of the samples. The majority of HPV (75.2%) were low-risk genotypes HPV6 and HPV11. Thus, HPV6 and HPV11 were most common infection in genital wart. We conclude that the quadrivalent vaccine could potentially prevent 84.5% of the genital warts found in the Thai population.
November 1, 2017

Background: Kawasaki disease (KD) is an immune-mediated systemic vasculitis and infection plays an important role in the pathophysiology of KD. The susceptibility to infectious disease in patients with KD remains largely unclear. This study aimed to investigate the risk of respiratory tract infection (RTI)-related hospitalizations in children with KD.

Methods: Data from Taiwanese National Health Insurance Research Database was analyzed. Children with KD were selected as KD group and age- and sex-matched non-KD patients were selected as control group with 1:1 ratio. Both cohorts were tracked for 1 year to investigate the incidences of RTI-related hospitalizations. Cox regression hazard model was used to adjust for confounding factors and calculate the adjusted hazard ratio (aHR).

Results: Between January 1996 and December 2012, 13,760 patients with KD were identified as KD group and 13,709 patients were enrolled as control group. An obviously reduced risk of RTI-related hospitalizations was observed in KD patients (aHR: 0.53, 95% confidence interval: 0.49-0.57). The decreased risk persisted through the 1-year follow-up period with a peak protection in 3-6 months (aHR: 0.46, 95% confidence interval: 0.40-0.53).

Conclusions: KD patients had approximately half reduction of risk for RTI-related hospitalizations. The protective effects persisted for at least 1 year. Further studies are warranted to elucidate the entire mechanism and investigate the influences of intravenous immunoglobulin.

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