[Experimental] List of manuscripts available for review volunteers
1 manuscript available for review volunteers
November 1, 2017

Background: Kawasaki disease (KD) is an immune-mediated systemic vasculitis and infection plays an important role in the pathophysiology of KD. The susceptibility to infectious disease in patients with KD remains largely unclear. This study aimed to investigate the risk of respiratory tract infection (RTI)-related hospitalizations in children with KD.

Methods: Data from Taiwanese National Health Insurance Research Database was analyzed. Children with KD were selected as KD group and age- and sex-matched non-KD patients were selected as control group with 1:1 ratio. Both cohorts were tracked for 1 year to investigate the incidences of RTI-related hospitalizations. Cox regression hazard model was used to adjust for confounding factors and calculate the adjusted hazard ratio (aHR).

Results: Between January 1996 and December 2012, 13,760 patients with KD were identified as KD group and 13,709 patients were enrolled as control group. An obviously reduced risk of RTI-related hospitalizations was observed in KD patients (aHR: 0.53, 95% confidence interval: 0.49-0.57). The decreased risk persisted through the 1-year follow-up period with a peak protection in 3-6 months (aHR: 0.46, 95% confidence interval: 0.40-0.53).

Conclusions: KD patients had approximately half reduction of risk for RTI-related hospitalizations. The protective effects persisted for at least 1 year. Further studies are warranted to elucidate the entire mechanism and investigate the influences of intravenous immunoglobulin.

FAQs

Is this open peer review?

No, peer review is still single-blind and all recommendations are private between the authors and Academic Editor. However, any reviewer has the option to sign their report, and once accepted for publication then that review can be shown publicly - again this is optional.

Will I be guaranteed to review if I volunteer?

No. Volunteering is not a guarantee that you will be asked to review. This is for many reasons. For one, reviewers must have relevant qualifications for any manuscript and void of any conflicts of interest. Additionally, it could be that enough reviewers have accepted an invitation to review already, in which case we would not invite any more.

Why aren't there more manuscripts available?

Manuscripts are shown when authors have opted-in for obtaining reviewers through the reviewer-match service. Additionally, there may already be enough reviewers found through other means, for example, invitations sent by the Academic Editor in charge.

What are the editorial criteria?

Please visit the editorial criteria page for initial guidance. You will also be given additional information if invited to review.