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evolutionary significance of venomics
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Can the authors provide information on, or speculate about the evolutionary significance of their data: that is, will the venome characteristics such as preponderance of MMPs and C-lectins, change in terrestrial pitvipers, or in other non-adder venomous snakes?

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For a broader discussion on the biological (and medical) significance of findings concerning venom proteomes, the following is an excellent reference: Calvete, J.J., 2013. Snake venomics: from the inventory of toxins to biology. Toxicon 75, 44–62. In addition, we have summarized the specific findings and implications of the proteomic analyses of venoms from snakes found in Costa Rica in the following article: Lomonte B, Fernández J, Sanz L, Angulo Y, Sasa M, Gutiérrez JM, Calvete JJ (2014) Venomous snakes of Costa Rica: biological and medical implications of their venom proteomic profiles analyzed through the strategy of "snake venomics". Journal of Proteomics 105, 323-339.

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