I am currrently analysing some fMRI data for language and visuospatial laterality. Basically, I administered a language task (verbal fluency) and a visuospatial task (visual short-term memory) during fMRI scanning.

Using meta-analyses I have identified key regions of interest in frontal-temporal language networks (e.g. inferior frontal gyrus, middle frontal gyrus, insula, anterior cingulate, thalamus) and key regions of interest in frontal-parietal-occipital visuospatial networks (e.g. superior frontal gyrus, inferior parietal gyrus, superior parietal gyrus, extrastriate cortex).

For my language laterality analyses, I examined cerebral activation by creating an inclusionary mask with all my language ROIs, .

For my visuospatial laterality analyses, I compared cerebral activation by creating an inclusionary mask with all my visuospatial ROIs.

I'm aware that this article recommends choosing one ROI that yields the most reliable results on laterality. However, I wanted to check if looking at the relevant regions as a whole makes more sense. Presumably, the ROIs regions work together during task performance, and should give us the most accurate picture of laterality for the appropriate cognitive function. Just wanted to check if I have missed something?