For eg the V600E BRAF mutation is present in different melanoma and colon cell lines. The same drug will have a different efficacy in different cell line harbouring the same mutation, because the mutated protein is in a different cellular mileu. So does this imply that wet experiments have to be performed first in different cell lines as well in a reductionist context for eg coexpressing V600E BRAF with the interacting protein and studying their interaction by Co-immunprecipitation and or co-localization in a kras null cell line (to nullify background effects) and then do the compuational experiment against these experiments and compare as a further step beyond comparing computational data withcell line data.