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Why larger species evolve more slowly than smaller species

Another accepted explanation would be a link to population size. Impact of high mutation rate is bigger in smaller population. Population size is then link to body mass or generation time !

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Accepted answer

I think by 'accepted explanation' you are suggesting the nearly neutral theory as a mechanism, whereby mildly deleterious mutations are eliminated more effectively in larger populations, thereby reducing the substitution rate. We deal with this in the paper, pointing out that the majority of microsatellites are neutral, so this model does not apply. However, even if most microsatellites are not perfectly neutral, there remains the intuitive problem of how selection can possibly act effectively against any particular new mutation causing the gain or loss of one repeat in the context of a genome that contains upwards of half a million microsatellites.

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