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In response to environmental and genetic perturbations, micro-organisms may regulate their metabolism both metabolically – via metabolite-enzyme interactions – and hierarchically – via modulating enzyme capacities. In this report, we develop a combined metabolic and genetic regulatory model of E. coli that may be used to test this multi-scale response.
This report is deliverable 4.6 of the EU FP7 (KBBE) grant 289434 "BioPreDyn: New Bioinformatics Methods and Tools for Data-Driven Predictive Dynamic Modelling in Biotechnological Applications".