The perilipins are lipid droplet surface proteins that contribute to fat metabolism by controlling the access of lipids to lipolytic enzymes. Perilipins have been identified in organisms as diverse as metazoa, fungi, and amoebas but strikingly not in nematodes. Here we identify the protein encoded by the
This is version 2 of a submission to PeerJ. An old version of Figure 1 is mistakenly submitted in version 1 and is corrected in version 2.
Three different protein isoforms are expressed from the
Panel A shows the genomic region of
The graph shows the effect of RNAi mediated knockdown of
The values show mild statistically significant difference in number of progeny laid by mutant worms CK123 compared to wild type N2 animals during the day 3 (Two Tailed T Test, p = 0.04962). Bars indicate SD.
The authors declare they have no competing interests.
The following information was supplied relating to ethical approvals (i.e., approving body and any reference numbers):
Human PLIN2 and PLIN3 were cloned from a collection of anonymous unmarked samples (PLIN2), and from human peripheral lymphocytes (PLIN3) donated by a volunteer with a written consent in compliance with the legislation of the Czech Republic and European Union (Act No 372/2011 of 11. 11. 2011 on Health Care Services, Coll., Paragraph 81, section 1a and section 4a, which is in accordance with the declaration of Helsinki and was approved by the Ethical Committee of the First Faculty of Medicine, Charles University in Prague).