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Additional Information

Competing Interests

Dr. Black is an Academic Editor for PeerJ.

Author Contributions

Brad D. Miller conceived and designed the experiments, performed the experiments, analyzed the data, wrote the paper.

Lauren A. Marks analyzed the data, reviewed and edited the manuscript.

Jonathan Koller analyzed the data, reviewed and edited the manuscript.

Blake J. Newman analyzed the data, reviewed and edited the manuscript.

G. Larry Bretthorst contributed reagents/materials/analysis tools, reviewed and edited the manuscript.

Kevin J Black conceived and designed the experiments, analyzed the data, wrote the paper.

Animal Ethics

The following information was supplied relating to ethical approvals (i.e., approving body and any reference numbers):

Washington University Animal Studies Committee, protocol # 20090112.

Grant Disclosures

The following grant information was disclosed by the authors:

U.S. National Institutes of Health (1R21MH081080, 3R21MH081080-01A1S1, K24MH087913, T35HL007815)

Funding

1. U.S. National Institutes of Health (1R21MH081080 and ARRA supplement 3R21MH081080-01A1S1; K24 MH087913; T35 HL007815) 2. McDonnell Center for Systems Neuroscience at Washington University 3. Boehringer-Ingelheim graciously provided the pramipexole. Boehringer-Ingelheim required that we administer no single dose higher than 0.2mg/kg i.v., but otherwise did not affect the study design, data collection, or analysis, or the writing of the manuscript.

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