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Additional Information

Competing Interests

The authors declare they have no competing interests.

Author Contributions

Humberto Fernandes conceived and designed the experiments, performed the experiments, analyzed the data, contributed reagents/materials/analysis tools, wrote the paper, prepared figures and/or tables, reviewed drafts of the paper.

Eoin N Leen conceived and designed the experiments, performed the experiments, analyzed the data, contributed reagents/materials/analysis tools, wrote the paper, prepared figures and/or tables, reviewed drafts of the paper.

Hamlet Cromwell Jnr performed the experiments, analyzed the data, contributed reagents/materials/analysis tools, reviewed drafts of the paper.

Marc-Philipp Pfeil performed the experiments, analyzed the data, contributed reagents/materials/analysis tools, reviewed drafts of the paper.

Stephen Curry conceived and designed the experiments, analyzed the data, contributed reagents/materials/analysis tools, wrote the paper, prepared figures and/or tables, reviewed drafts of the paper.

Data Deposition

The following information was supplied regarding the deposition of related data:

RCSB protein data bank:

4x2v

4x2w

4x2x

4x2y

Funding

This work was supported in part by grant funding from the Biotechnology and Biological Sciences Research Council, UK (Ref: BB/J001708/1). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.


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