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Additional Information

Competing Interests

The authors declare they have no competing interests.

Author Contributions

Fanshuang Zhang conceived and designed the experiments, performed the experiments, analyzed the data, contributed reagents/materials/analysis tools, wrote the paper, prepared figures and/or tables, reviewed drafts of the paper.

Yuan Yuan contributed reagents/materials/analysis tools.

Jianqiang Wu analyzed the data.

Youhe Gao conceived and designed the experiments.

Human Ethics

The following information was supplied relating to ethical approvals (i.e., approving body and any reference numbers):

IRB of the Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, approval number 040-2014

Funding

Funding was provided by the National Basic Research Program of China (2012CB517606, 2013CB530805), the Key Basic Research Program of the Ministry of Science and Technology of China (No. 2013FY114100), 111 Project (B08007), the PUMC Youth Fund and the Fundamental Research Funds for the Central Universities (33320140133). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.


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