Brainstem projections to molecular layer heterotopia of the cerebellar vermis: Evidence from the Allen Mouse Brain Connectivity Database
- Published
- Accepted
- Subject Areas
- Neuroscience
- Keywords
- cerebellum, malformation, axons, heterotopia
- Copyright
- © 2014 Ramos
- Licence
- This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ PrePrints) and either DOI or URL of the article must be cited.
- Cite this article
- 2014. Brainstem projections to molecular layer heterotopia of the cerebellar vermis: Evidence from the Allen Mouse Brain Connectivity Database. PeerJ PrePrints 2:e562v1 https://doi.org/10.7287/peerj.preprints.562v1
Abstract
Molecular layer heterotopia of the cerebellar vermis are a characteristic feature of C57BL/6 mice. Heterotopia consist of neurons and glia in the molecular layers between folia VIII and IX in regions lacking pia. Previously, we described the cellular composition of heterotopia which includes granule cells, Purkinje cells, Golgi cells, etc. However, the axonal constituents and afferent connections of these malformations remain poorly understood. In the present report axonal projections to heterotopia are documented from diverse brainstem nuclei such as the spinal vestibular nucleus, dorsal cochlear nucleus, and nucleus prepositus. These findings are relevant toward understanding the mechanisms of normal and abnormal cerebellar development and the establishment of cerebellar circuits.
Author Comment
This manuscript is submitted to PeerJ for review.