A new potentially promising concept in diagnosis of occult infection with help of PET-CT
- Published
- Accepted
- Subject Areas
- Microbiology, Infectious Diseases, Radiology and Medical Imaging, Surgery and Surgical Specialties
- Keywords
- fever of unknown origin, Diagnosis of occult infection, PET-CT in diagnosis of occult infection, PET-CT in diagnosis of infectious complications, radiopharmaceutical agents
- Copyright
- © 2013 Sarsenov et al.
- Licence
- This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Cite this article
- 2013. A new potentially promising concept in diagnosis of occult infection with help of PET-CT. PeerJ PrePrints 1:e52v1 https://doi.org/10.7287/peerj.preprints.52v1
Abstract
In the light of recent advances in radionuclide diagnostics of occult infectious states, it is clearly seen that positron emission tomography will have a part in routine work-up especially for critically ill patients in near future. For the purpose of further development of a specific agent that might be capable of detecting a living microorganism in occult focus inside the host organism, we come with a concept of probably a new radiopharmaceutical agent besides well-known fluorinated glucose, labelled leucocytes and gallium based radiopharmaceuticals. The aim of this opinion letter is to propose a specific agent for almost all bacteria and fungi genera not depending on host’s metabolism, thus letting differentiation of infection foci from host’s tissue. The discussion of this letter is mainly on the background of developing a compound for folate biosynthesis in bacteria and fungi which is a specific way of metabolization by the mentioned species which is provided by microbiological studies.
Author Comment
With this letter originating from current status of literature we try to state a potentially new concept aiming to provide a more specific way of evaluating interaction between host and microbiome in its wide meaning.