Arterial spin labeling versus BOLD in pharmacological fMRI
- Published
- Accepted
- Subject Areas
- Neuroscience, Neurology
- Keywords
- phMRI (pharmacological fMRI), functional magnetic resonance imaging, pulsed arterial spin labeling, tozadenant, statistical parametric mapping, arterial spin labeling, arterial spin labeling (ASL), BOLD, Parkinson disease
- Copyright
- © 2014 Stewart et al.
- Licence
- This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ PrePrints) and either DOI or URL of the article must be cited.
- Cite this article
- 2014. Arterial spin labeling versus BOLD in pharmacological fMRI. PeerJ PrePrints 2:e493v1 https://doi.org/10.7287/peerj.preprints.493v1
Abstract
A carefully controlled study allowed us to compare the sensitivity of ASL (arterial spin labeling) and BOLD (blood oxygen level dependent) fMRI for detecting the effects of the adenosine A2a antagonist tozadenant in Parkinson disease . Only ASL detected the direct effect of tozadenant. BOLD was more sensitive to a cognitive task, which (unlike most drugs) allows on-off comparisons over short periods of time. Neither ASL nor BOLD could detect a cognitive-pharmacological interaction. These results are consistent with the known relative advantages of each fMRI method, and suggest that for drug development, directly imaging pharmacodynamic effects with ASL may have advantages over cognitive-pharmacological interaction BOLD, which has hitherto been the more common approach to pharmacological fMRI.
Author Comment
This is a submission to PeerJ for review.