Placental vascular pathology and increased thrombin generation as mechanisms of disease in obstetrical syndromes

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1 Department of Obstetrics and Gynecology, Azienda Ospedaliero-Universitaria Policlinico di Bari, School of Medicine, University of Bari "Aldo Moro", Bari, Italy
2 Obstetrics and Gynecology, Soroka University Medical Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
3 Department of Obstetrics and Gynecology, Azienda Ospedaliero-Universitaria Policlinico di Bari, School of Medicine, University of Bari, Bari, Italy
DOI
10.7287/peerj.preprints.487v1
Published
Accepted
Subject Areas
Gynecology and Obstetrics, Hematology
Keywords
Coagulation, TAT III complexes, TFPI, Protein Z, Amniotic Fluid, IUGR, PROM, Preeclampsia, Fetal demise, Preterm labor
Copyright
© 2014 Mastrolia et al.
Licence
This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ PrePrints) and either DOI or URL of the article must be cited.
Cite this article
Mastrolia SA, Mazor M, Loverro G, Klaitman V, Erez O. 2014. Placental vascular pathology and increased thrombin generation as mechanisms of disease in obstetrical syndromes. PeerJ PrePrints 2:e487v1

Abstract

Obstetrical complications including preeclampsia, fetal growth restriction, preterm labor, preterm prelabor rupture of membranes and fetal demise are all the clinical endpoint of several underlying mechanisms (i.e. infection inflammation, thrombosis, endocrine disorder, immunologic rejection, genetic, and environmental), therefore, they may be regarded as syndromes. Placental vascular pathology and increased thrombin generation were reported in all of these obstetrical syndromes. Moreover, elevated concentrations of thrombin-anti-thrombin III complexes and changes in the coagulation as well as anticoagulation factors can be detected in the maternal circulation prior to the clinical development of the disease in some of these syndromes. In this review, we will assess the changes in the hemostatic system during normal and complicated pregnancy in maternal blood, maternal-fetal interface and amniotic fluid, and describe the contribution of thrombosis and vascular pathology to the development of the great obstetrical syndromes.

Author Comment

This is a submission to PeerJ for review.