The physiologic and therapeutic role of Heparin in implantation and placentation
- Published
- Accepted
- Subject Areas
- Gynecology and Obstetrics, Immunology
- Keywords
- glycosaminoglycan, Glycosaminoglycan, Trophoblast, Selectins, Cadherins, HB-EGF, Matrix metalloproteinases, Immune system
- Copyright
- © 2014 Quaranta et al.
- Licence
- This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ PrePrints) and either DOI or URL of the article must be cited.
- Cite this article
- 2014. The physiologic and therapeutic role of Heparin in implantation and placentation. PeerJ PrePrints 2:e486v1 https://doi.org/10.7287/peerj.preprints.486v1
Abstract
Implantation, trophoblast development and placentation are crucial processes in the establishment and development of normal pregnancy. Abnormalities of these processes can lead to pregnancy complications named the great obstetrical syndromes (preeclampsia, intrauterine growth restriction, fetal demise, premature prelabor rupture or membranes, preterm labor, and recurrent pregnancy loss). There is mounting evidence regarding the physiological and therapeutic role of heparins in the establishment of normal gestation and as a modality for treatment and prevention of pregnancy complications. In this review we will summarize the properties and the physiological contribute of heparins to the success of implantation and placentation and normal pregnancy.
Author Comment
This is a submission to PeerJ for review.