The physiologic and therapeutic role of Heparin in implantation and placentation

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1 Department of Obstetrics and Gynaecology, Azienda Ospedaliera Universitaria Integrata - Università degli Studi di Verona, Verona, Italy
2 Obstetrics and Gynecology, Soroka University Medical Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
3 Department of Obstetrics and Gynecology, Azienda Ospedaliero-Universitaria Policlinico di Bari, School of Medicine, University of Bari "Aldo Moro", Bari, Italy
DOI
10.7287/peerj.preprints.486v1
Published
Accepted
Subject Areas
Gynecology and Obstetrics, Immunology
Keywords
glycosaminoglycan, Glycosaminoglycan, Trophoblast, Selectins, Cadherins, HB-EGF, Matrix metalloproteinases, Immune system
Copyright
© 2014 Quaranta et al.
Licence
This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ PrePrints) and either DOI or URL of the article must be cited.
Cite this article
Quaranta M, Erez O, Mastrolia SA, Koifman A, Leron E, Eshkoli T, Mazor M, Holcberg G. 2014. The physiologic and therapeutic role of Heparin in implantation and placentation. PeerJ PrePrints 2:e486v1

Abstract

Implantation, trophoblast development and placentation are crucial processes in the establishment and development of normal pregnancy. Abnormalities of these processes can lead to pregnancy complications named the great obstetrical syndromes (preeclampsia, intrauterine growth restriction, fetal demise, premature prelabor rupture or membranes, preterm labor, and recurrent pregnancy loss). There is mounting evidence regarding the physiological and therapeutic role of heparins in the establishment of normal gestation and as a modality for treatment and prevention of pregnancy complications. In this review we will summarize the properties and the physiological contribute of heparins to the success of implantation and placentation and normal pregnancy.

Author Comment

This is a submission to PeerJ for review.