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Cite this article
Stewart SB, Koller JM, Campbell MC, Perlmutter JS, Black KJ. (2014) Additive global cerebral blood flow normalization in arterial spin labeling perfusion imaging. PeerJ PrePrints2:e464v3https://doi.org/10.7287/peerj.preprints.464v3
To determine how different methods of normalizing for global cerebral blood flow (gCBF) affect image quality and sensitivity to cortical activation, pulsed arterial spin labeling (pASL) scans obtained during a visual task were normalized by either additive or multiplicative normalization of modal gCBF. Normalization by either method increased the statistical significance of cortical activation by a visual stimulus. However, image quality was superior with additive normalization, whether judged by intensity histograms or by reduced variability within gray and white matter.
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