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Stewart SB, Koller JM, Campbell MC, Perlmutter JS, Black KJ.2014. Additive global cerebral blood flow normalization in arterial spin labeling perfusion imaging. PeerJ PrePrints2:e464v3https://doi.org/10.7287/peerj.preprints.464v3
To determine how different methods of normalizing for global cerebral blood flow (gCBF) affect image quality and sensitivity to cortical activation, pulsed arterial spin labeling (pASL) scans obtained during a visual task were normalized by either additive or multiplicative normalization of modal gCBF. Normalization by either method increased the statistical significance of cortical activation by a visual stimulus. However, image quality was superior with additive normalization, whether judged by intensity histograms or by reduced variability within gray and white matter.
This is an updated version to address reviewers' comments.