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Sideritis scardica extracts inhibit aggregation and toxicity of amyloid-β in Caenorhabditis elegans used as a model for Alzheimer's disease

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Sideritis scardica extracts inhibit aggregation and toxicity of amyloid-β in Caenorhabditis elegans used as a model for Alzheimer's disease https://t.co/iK0IExM6ry
210 days ago
Sideritis scardica extracts inhibit aggregation and toxicity of amyloid-β in Caenorhabditis elegans used as a model for Alzheimer's disease https://t.co/1Vvogop7E8
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Supplemental Information

Growth control of worms treated with the substances

The worms were treated with the highest used concentrations of the extracts and fractions. A reduced body length would point to toxic effects to the worms or antimicrobial properties against the food source of the worms (E. coli). All concentrations were deemed suitable

DOI: 10.7287/peerj.preprints.3483v1/supp-6

Raw data of A beta plaques

Single values (mean plaque number of 20-25 worms) of up to 4 independently performed experiments. Results: means, SEM, statistics

DOI: 10.7287/peerj.preprints.3483v1/supp-7

Raw data of paralysis assay

First sheet: Single values (median values obtained from Kaplan-Meier analysis) of 4 independently performed experiments. Results: means, SEM, statistics

Second sheet: % of worms (test strain CL4176 expressing A beta) not paralysed for every time point. Data used for creating the graphs

Third sheet: % of worms (control strain CL802 not expressing A beta) not paralysed for every time point. Worms were treated with the highest concentration of the respective extract/ fraction. As worms were not paralysing, the delayed paralysis of CL4176 can be attributed to A beta-counteracting effects of the test substances.

DOI: 10.7287/peerj.preprints.3483v1/supp-8

Additional Information

Competing Interests

Björn Feistel is head of scientific affairs at Finzelberg GmbH & Co. KG.

Michael Wink is an Academic Editor for PeerJ.

Author Contributions

Felix Heiner conceived and designed the experiments, performed the experiments, analyzed the data, wrote the paper, prepared figures and/or tables.

Björn Feistel conceived and designed the experiments, analyzed the data, contributed reagents/materials/analysis tools, reviewed drafts of the paper.

Michael Wink analyzed the data, contributed reagents/materials/analysis tools, reviewed drafts of the paper.

Funding

The authors received no funding for this work.


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