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Additional Information

Competing Interests

Michela Quadrini is a PhD Candidate in Computer Science at University of Camerino. She works with the “BioShape and BigData Lab” research group at the Computer Science Department. Her research interests lie at the intersection of Computer Science, Mathematics and Molecular Biology, with a special focus on RNA biology. Her research has been focused on algebraic representation of RNA secondary structures, with a particular attention on pseudoknoted structures characterized by crossing interactions.

Author Contributions

Michela Quadrini contributed reagents/materials/analysis tools, wrote the paper, prepared figures and/or tables, reviewed drafts of the paper.

Luca Tesei contributed reagents/materials/analysis tools, wrote the paper, reviewed drafts of the paper.

Emanuela Merelli wrote the paper, reviewed drafts of the paper.

Data Deposition

The following information was supplied regarding data availability:

The research in this article did not generate any data or code.


This work was supported by the Future and Emerging Technologies (FET) programme within the Seventh Framework Programme (FP7) for Research of the European Commission, under the FET-Proactive grant agreement TOPDRIM (, number FP7-ICT- 318121 The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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