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Interaction of antimutagenic 1,4-dihydropyridine AV-153-Na with DNA and DNA-damaging molecules and its impact on DNA repair activity

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68 days ago
Interaction of antimutagenic 1,4-dihydropyridine AV-153-Na with DNA and DNA-damaging molecules and its impact on… https://t.co/sg6GhUdQJg
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Supplemental Information

Effects of AV-153-Na (3h incubation) against peroxinitrite

Figure 9 (B)

DOI: 10.7287/peerj.preprints.3317v1/supp-1

Effects of AV-153-Na on the activity of DNA repair enzymes

Figures 10 and 11

DOI: 10.7287/peerj.preprints.3317v1/supp-2

Effect of AV-153-Na (45 min) against peroxynitrite

Figure 9 (A)

DOI: 10.7287/peerj.preprints.3317v1/supp-3

Effect of AV-154-Na (45 min) agaist peroxynitrite

Figure 9 (C)

DOI: 10.7287/peerj.preprints.3317v1/supp-4

Additional Information

Competing Interests

The authors declare that they have no competing interests

Author Contributions

Elina Leonova conceived and designed the experiments, performed the experiments, analyzed the data, wrote the paper, prepared figures and/or tables, reviewed drafts of the paper.

Evita Rostoka conceived and designed the experiments, performed the experiments, analyzed the data, wrote the paper, prepared figures and/or tables, reviewed drafts of the paper.

Sylvie Sauvaigo conceived and designed the experiments, performed the experiments, analyzed the data, contributed reagents/materials/analysis tools, wrote the paper, reviewed drafts of the paper.

Edgars Smelovs performed the experiments, analyzed the data, prepared figures and/or tables.

Larisa Baumane performed the experiments, contributed reagents/materials/analysis tools, wrote the paper.

Vitalijs Borisovs performed the experiments.

Turs Selga conceived and designed the experiments, contributed reagents/materials/analysis tools.

Nikolajs Sjakste conceived and designed the experiments, analyzed the data, wrote the paper, prepared figures and/or tables, reviewed drafts of the paper.

Data Deposition

The following information was supplied regarding data availability:

NA

Funding

The work was supported from the State Research Program “Biomedicine 2014”. Collaboration between French and Latvian teams was supported by a project of the Osmose programme. We thank U. Kalnenieks and R. Rutkis (Institute of Microbiology and Biotechnology of the University of Latvia) for giving access to their equipment The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.


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