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Additional Information

Competing Interests

The authors declare that they have no competing interests.

Author Contributions

Noemi Di Nanni conceived and designed the experiments, analyzed the data, contributed reagents/materials/analysis tools, wrote the paper, prepared figures and/or tables.

Matteo Gnocchi contributed reagents/materials/analysis tools, computational infrastructure management.

Marco Moscatelli contributed reagents/materials/analysis tools, computational infrastructure management.

Luciano Milanesi conceived and designed the experiments, contributed reagents/materials/analysis tools, reviewed drafts of the paper.

Ettore Mosca conceived and designed the experiments, analyzed the data, contributed reagents/materials/analysis tools, wrote the paper, prepared figures and/or tables, reviewed drafts of the paper.

Data Deposition

The following information was supplied regarding data availability:

The research in this article did not generate any data or code.

Funding

The work has been supported by: the EU FP7 project “MIMOmics” (305280); the Italian Ministry of Education, University and Research (MIUR) projects “INTEROMICS” (PB05) and “PRIN 2015”; the Lombardy Region Foundation FRRB project “LYRA” (2015-0010). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.


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