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Additional Information

Competing Interests

The authors have no competing interests in relation to all topics covered in this paper.

Author Contributions

John A Medeiros conceived and designed the experiments, performed the experiments, analyzed the data, wrote the paper, prepared figures and/or tables, reviewed drafts of the paper.

Nancy E Medeiros performed the experiments, reviewed drafts of the paper, material discussions on numerous topics covered in the paper.


No external funding sources were used to support this work. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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