Visitors   Views   Downloads
NOT PEER-REVIEWED
"PeerJ Preprints" is a venue for early communication or feedback before peer review. Data may be preliminary.

Supplemental Information

Additional file 1: Sensitivity analyses of the representativeness of the CPRD

DOI: 10.7287/peerj.preprints.3238v1/supp-1

Additional file 2: Medical code lists

DOI: 10.7287/peerj.preprints.3238v1/supp-2

Additional file 3: Product code lists

DOI: 10.7287/peerj.preprints.3238v1/supp-3

Additional file 4: Sensitivity analyses of the diagnosis definitions using linked data

DOI: 10.7287/peerj.preprints.3238v1/supp-4

Additional file 5: ICD-10 code lists

DOI: 10.7287/peerj.preprints.3238v1/supp-5

Additional file 6: Model specifications for the joinpoint analyses

DOI: 10.7287/peerj.preprints.3238v1/supp-6

Additional file 7: Analysis for the diagnosis ‘probable Alzheimer’s disease’

DOI: 10.7287/peerj.preprints.3238v1/supp-7

Additional file 8: Analysis for the diagnosis ‘any Alzheimer’s disease’

DOI: 10.7287/peerj.preprints.3238v1/supp-8

Additional file 9: Analysis for the diagnosis ‘any dementia’

DOI: 10.7287/peerj.preprints.3238v1/supp-9

Additional Information

Competing Interests

The authors declare that they have no competing interests.

Author Contributions

Venexia M Walker conceived and designed the experiments, analyzed the data, wrote the paper, prepared figures and/or tables, reviewed drafts of the paper.

Neil M Davies conceived and designed the experiments, reviewed drafts of the paper.

Patrick G Kehoe conceived and designed the experiments, reviewed drafts of the paper.

Richard M Martin conceived and designed the experiments, reviewed drafts of the paper.

Human Ethics

The following information was supplied relating to ethical approvals (i.e., approving body and any reference numbers):

The protocol for this study has been approved by the CPRD’s Independent Scientific Advisory Committee [ISAC Protocol 15_246R]. This study does not directly involve patients so further ethical approval is not required.

Data Deposition

The following information was supplied regarding data availability:

We have deposited the code related to this manuscript, the details of which are provided below:

1) GitHub

2) venexia/DementiaDrugsCPRD

3) https://github.com/venexia/DementiaDrugsCPRD

Funding

This work was supported by the Perros Trust and the Integrative Epidemiology Unit. The Integrative Epidemiology Unit is supported by the Medical Research Council and the University of Bristol [grant number MC_UU_12013/9]. PGK has a Professorship supported by the Sigmund Gestetner Foundation. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.


Add your feedback

Before adding feedback, consider if it can be asked as a question instead, and if so then use the Question tab. Pointing out typos is fine, but authors are encouraged to accept only substantially helpful feedback.

Some Markdown syntax is allowed: _italic_ **bold** ^superscript^ ~subscript~ %%blockquote%% [link text](link URL)
 
By posting this you agree to PeerJ's commenting policies