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Supplemental Information

raw data for Figs. 1, 2, 3, and 6

DOI: 10.7287/peerj.preprints.3227v1/supp-1

raw data for Figs. 4, 5, and 7

DOI: 10.7287/peerj.preprints.3227v1/supp-2

Additional Information

Competing Interests

The authors declare that they have no competing interests.

Author Contributions

Toshiaki Ara conceived and designed the experiments, performed the experiments, analyzed the data, contributed reagents/materials/analysis tools, wrote the paper, prepared figures and/or tables, reviewed drafts of the paper, lstatistical analysis.

Norio Sogawa conceived and designed the experiments, analyzed the data, reviewed drafts of the paper.

Human Ethics

The following information was supplied relating to ethical approvals (i.e., approving body and any reference numbers):

Ethical Committee of Matsumoto Dental University (No. 0063).


The study was supported by funding from JSPS KAKENHI Grant Number JP16H05144, the Nagano Society for the Promotion of Science, and a Scientific Research Special Grant from Matsumoto Dental University. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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