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Additional Information

Competing Interests

The authors declare that they have no competing interests.Wenhao Yang, Guijun Liu, Gaoshui Yu and Peng Wang are employees of Shandong Lukang Shelile Pharmaceutical Co., LTD.

Author Contributions

Wenhao Yang conceived and designed the experiments, performed the experiments, wrote the paper.

Mengjiao Guo conceived and designed the experiments, performed the experiments, wrote the paper.

Guijun Liu analyzed the data.

Gaoshui Yu analyzed the data.

Peng Wang analyzed the data.

Tongjie Chai wrote the paper, reviewed drafts of the paper.

Hairong Wang contributed reagents/materials/analysis tools, prepared figures and/or tables.

Data Deposition

The following information was supplied regarding data availability:

The raw data/code is included in the manuscript (The raw data is included in the results).

Funding

This study was sponsored by the National Science and Technology Support Project (2012BAD39B0205); Key Research Project of Shandong Province (2016GNC110014); National Natural Science Foundation of China (31470258). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.


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