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Additional Information

Competing Interests

The authors declare that they have no competing interests.

Author Contributions

Ernest Awoonor-Williams conceived and designed the experiments, performed the experiments, analyzed the data, contributed reagents/materials/analysis tools, wrote the paper, prepared figures and/or tables, reviewed drafts of the paper.

Andrew G Walsh conceived and designed the experiments, performed the experiments, analyzed the data, contributed reagents/materials/analysis tools, prepared figures and/or tables.

Christopher N Rowley conceived and designed the experiments, performed the experiments, analyzed the data, contributed reagents/materials/analysis tools, wrote the paper, prepared figures and/or tables, reviewed drafts of the paper.

Data Deposition

The following information was supplied regarding data availability:

This is a review article.

Funding

This work was supported by NSERC of Canada through the Discovery Grant program (Application 418505-2012). EAW received a graduate fellowship from the School of Graduate Studies at Memorial University and ACENET for an Advanced Research Computing Fellowship. Computational resources were provided by Compute Canada (RAPI: djk-615-ab) through the Calcul Quebec, Westgrid, and ACENET consortia. Schrodinger Inc. provided a temporary license of Maestro/Glide. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.


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